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SERPINH1 recombinant protein

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Catalog # MBS8249780
Unit / Price
  0.01 mg  /  $255 +1 FREE 8GB USB
  0.05 mg  /  $635 +1 FREE 8GB USB
  0.5 mg  /  $2,370 +2 FREE 8GB USB
SERPINH1 recombinant protein
Product Name

SERPINH1, Recombinant Protein

Popular Item
Also Known As

Recombinant Human SERPINH1 Protein

Product Synonym Names
CBP1; CBP2; HSP47; SERPINH2; Serpin H1; 47 kDa heat shock protein; Arsenic-transactivated protein 3; AsTP3; Cell proliferation-inducing gene 14 protein; Collagen-binding protein; Colligin; Rheumatoid arthritis-related antigen RA-A47
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
418
Sequence
AEVKKPAAAA APGTAEKLSP KAATLAERSA GLAFSLYQAM AKDQAVENIL VSPVVVASSL GLVSLGGKAT TASQAKAVLS AEQLRDEEVH AGLGELLRSL SNSTARNVTW KLGSRLYGPS SVSFADDFVR SSKQHYNCEH SKINFRDKRS ALQSINEWAA QTTDGKLPEV TKDVERTDGA LLVNAMFFKP HWDEKFHHKM VDNRGFMVTR SYTVGVMMMH RTGLYNYYDD EKEKLQIVEM PLAHKLSSLI ILMPHHVEPL ERLEKLLTKE QLKIWMGKMQ KKAVAISLPK GVVEVTHDLQ KHLAGLGLTE AIDKNKADLS RMSGKKDLYL ASVFHATAFE LDTDGNPFDQ DIYGREELRS PKLFYADHPF IFLVRDTQSG SLLFIGRLVR PKGDKMRDEL VDHHHHHH
OMIM
X61598 mRNA
3D Structure
ModBase 3D Structure for P50454
Species Reactivity
Human
Purity/Purification
Greater than 95% as determined by reducing SDS-PAGE.
Form/Format
Lyophilized from a 0.2 muM filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
Source
Human cells
Endotoxin
Less than 0.1 ng/mug (1 IEU/mug) as determined by LAL test.
Directions for Use
Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 mug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Preparation and Storage
Lyophilized protein should be stored at -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at -20 degree C for 3 months.
Other Notes
Small volumes of SERPINH1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
SERPINH1 recombinant protein
Recombinant Human SERPINH1 Protein is produced by our Mammalian expression system and the target gene encoding Ala19-Leu418 is expressed with a 6His tag at the C-terminus.
Applications Tested/Suitable for SERPINH1 recombinant protein
ELISA (EIA),Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)
NCBI/Uniprot data below describe general gene information for SERPINH1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46,441 Da
NCBI Official Full Name
serpin H1
NCBI Official Synonym Full Names
serpin family H member 1
NCBI Official Symbol
SERPINH1  [Similar Products]
NCBI Official Synonym Symbols
CBP1; CBP2; OI10; gp46; AsTP3; HSP47; PIG14; PPROM; RA-A47; SERPINH2
  [Similar Products]
NCBI Protein Information
serpin H1
UniProt Protein Name
Serpin H1
UniProt Synonym Protein Names
47 kDa heat shock protein; Arsenic-transactivated protein 3; AsTP3; Cell proliferation-inducing gene 14 protein; Collagen-binding protein; Colligin; Rheumatoid arthritis-related antigen RA-A47
Protein Family
UniProt Gene Name
SERPINH1  [Similar Products]
UniProt Synonym Gene Names
CBP1; CBP2; HSP47; SERPINH2; AsTP3; Colligin  [Similar Products]
UniProt Entry Name
SERPH_HUMAN
NCBI Summary for SERPINH1
This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]
UniProt Comments for SERPINH1
SERPINH1: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. Defects in SERPINH1 are the cause of osteogenesis imperfecta type 10 (OI10). A connective tissue disorder characterized by bone fragility, low bone mass, bowing of limbs due to multiple fractures, short limb dwarfism and blue sclerae. Belongs to the serpin family.

Chromosomal Location of Human Ortholog: 11q13.5

Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen; ER-Golgi intermediate compartment; extracellular space; lipid raft

Molecular Function: collagen binding

Biological Process: collagen fibril organization; response to unfolded protein

Disease: Osteogenesis Imperfecta, Type X; Preterm Premature Rupture Of The Membranes
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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