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SETDB2 peptide

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Catalog # MBS427400
Unit / Price
  0.1 mg  /  $190 +1 FREE 8GB USB
SETDB2 peptide
Product Name

SETDB2, Peptide

Full Product Name

SETDB2 Immunizing Peptide

Product Synonym Names
SETDB2; SET domain, bifurcated 2; C13orf4; CLLD8; CLLL8; DKFZp586I0123; DKFZp761J1217; KMT1F; OTTHUMP00000018418; chronic lymphocytic leukemia deletion region 8; chronic lymphocytic leukemia deletion region gene 8 protein; histone-lysine N-methyltransfera
Product Gene Name
Antibody/Peptide Pairs
SETDB2 peptide (MBS427400) is used for blocking the activity of SETDB2 antibody (MBS422716)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
C-QRRHAKTN SHSSALH
OMIM
607865
Species Reactivity
Human, Mouse, Dog, Pig, Cow
Form/Format
100ug of dried peptide
Preparation and Storage
Shipped at ambient temperature, store at -20 degree C
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of SETDB2 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for SETDB2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
Manufactured in an ISO 9001:2015 Certified Laboratory.NP_001153780.1[Other Products]
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
81,766 Da
NCBI Official Full Name
histone-lysine N-methyltransferase SETDB2 isoform a
NCBI Official Synonym Full Names
SET domain bifurcated 2
NCBI Official Symbol
SETDB2  [Similar Products]
NCBI Official Synonym Symbols
CLLD8; CLLL8; KMT1F; C13orf4
  [Similar Products]
NCBI Protein Information
histone-lysine N-methyltransferase SETDB2
UniProt Protein Name
Histone-lysine N-methyltransferase SETDB2
UniProt Synonym Protein Names
Chronic lymphocytic leukemia deletion region gene 8 protein; Lysine N-methyltransferase 1F; SET domain bifurcated 2
UniProt Gene Name
SETDB2  [Similar Products]
UniProt Synonym Gene Names
C13orf4; CLLD8; KMT1F  [Similar Products]
UniProt Entry Name
SETB2_HUMAN
NCBI Summary for SETDB2
This gene encodes a member of a family of proteins that contain a methyl-CpG-binding domain (MBD) and a SET domain and function as histone methyltransferases. This protein is recruited to heterochromatin and plays a role in the regulation of chromosome segregation. This region is commonly deleted in chronic lymphocytic leukemia. Naturally-occuring readthrough transcription occurs from this gene to the downstream PHF11 (PHD finger protein 11) gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
UniProt Comments for SETDB2
SETDB2: Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis. Belongs to the histone-lysine methyltransferase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.1.1.43; Amino Acid Metabolism - lysine degradation; Methyltransferase; Methyltransferase, protein lysine

Chromosomal Location of Human Ortholog: 13q14

Cellular Component: chromosome; nucleoplasm; nucleus

Molecular Function: DNA binding; histone lysine N-methyltransferase activity (H3-K9 specific); histone-lysine N-methyltransferase activity; protein binding; zinc ion binding

Biological Process: cell division; chromosome segregation; heart looping; histone H3-K9 methylation; mitosis; negative regulation of transcription, DNA-dependent
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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