NP_001276346.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
20,644 Da
NCBI Official Full Name
anaphase-promoting complex subunit 11 isoform 2
NCBI Official Synonym Full Names
anaphase promoting complex subunit 11
NCBI Protein Information
anaphase-promoting complex subunit 11; cyclosome subunit 11; APC11 anaphase promoting complex subunit 11 homolog; hepatocellular carcinoma-associated RING finger protein; anaphase promoting complex subunit 11 (yeast APC11 homolog)
UniProt Protein Name
Anaphase-promoting complex subunit 11
UniProt Synonym Protein Names
Cyclosome subunit 11; Hepatocellular carcinoma-associated RING finger protein
UniProt Synonym Gene Names
UniProt Entry Name
APC11_HUMAN
UniProt Comments for ANAPC11
APC11: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. Belongs to the RING-box family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin ligase; Ligase; Ubiquitin conjugating system; Cell cycle regulation; EC 6.3.2.-
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: nucleoplasm; anaphase-promoting complex; nucleolus; cytosol
Molecular Function: zinc ion binding; ubiquitin-protein ligase activity
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; cell division; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle spindle assembly checkpoint; protein ubiquitination; mitotic cell cycle
Research Articles on ANAPC11
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Products associated with ANAPC11 elisa kit
Pathways associated with ANAPC11 elisa kit
Diseases associated with ANAPC11 elisa kit
Organs/Tissues associated with ANAPC11 elisa kit
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