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SIGLEC1 recombinant protein :: Sialic Acid Binding Ig Like Lectin 1 (SIGLEC1) Recombinant Protein

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Catalog # MBS2009590 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
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  0.01 mg  /  $125 +1 FREE 8GB USB
  0.05 mg  /  $225 +1 FREE 8GB USB
  0.1 mg  /  $330 +1 FREE 8GB USB
  0.2 mg  /  $405 +1 FREE 8GB USB
  0.5 mg  /  $780 +1 FREE 8GB USB
  1 mg  /  $1,150 +1 FREE 8GB USB
SDS-Page
Product Name

Sialic Acid Binding Ig Like Lectin 1 (SIGLEC1), Recombinant Protein

Popular Item
Full Product Name

Recombinant Sialic Acid Binding Ig Like Lectin 1 (SIGLEC1)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
The target protein is fused with N-terminal His-Tag, its sequence is listed below.
MGHHHHHHSG SEF- PEGAPITVT CADPAAHAPT LYTWYHNGRW LQEGPAASLS FLVATRAHAG AYSCQAQDAQ GTRSSRPAAL QVLYAPQDAV LSSFRDSRAR SMAVIQCTVD SEPPAELALS HDGKVLATSS GVHSLASGTG HVQVARNALR L
Chromosome Location
Chromosome: 20; NC_000020.10 (3667617..3693213, complement). Location: 20p13
OMIM
600751
3D Structure
ModBase 3D Structure for Q9BZZ2
Host
E Coli
Purity/Purification
> 95%
Form/Format
Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
Organism
Homo sapiens (Human)
Expression System
Prokaryotic expression
Residues
Pro1272~Leu1411 (Accession # Q9BZZ2) with N-terminal His-Tag
Endotoxin Level
<1.0EU per 1ug (determined by the LAL method)
Reconstitution
Reconstitute in sterile PBS, pH7.2-pH7.4.
Preparation and Storage
Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of SIGLEC1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
SIGLEC1 recombinant protein
About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.
Applications Tested/Suitable for SIGLEC1 recombinant protein
SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

NCBI/Uniprot data below describe general gene information for SIGLEC1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16.2kDa
NCBI Official Full Name
sialoadhesin
NCBI Official Synonym Full Names
sialic acid binding Ig-like lectin 1, sialoadhesin
NCBI Official Symbol
SIGLEC1  [Similar Products]
NCBI Official Synonym Symbols
SN; CD169; SIGLEC-1; dJ1009E24.1
  [Similar Products]
NCBI Protein Information
sialoadhesin; sialic acid-binding Ig-like lectin 1; sialic acid-binding immunoglobulin-like lectin 1
UniProt Protein Name
Sialoadhesin
UniProt Synonym Protein Names
Sialic acid-binding Ig-like lectin 1
Protein Family
UniProt Gene Name
SIGLEC1  [Similar Products]
UniProt Synonym Gene Names
SN; Siglec-1  [Similar Products]
UniProt Entry Name
SN_HUMAN
NCBI Summary for SIGLEC1
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for SIGLEC1
SIGLEC1: Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hemopoiesis. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: integral to membrane; plasma membrane; extracellular region

Molecular Function: carbohydrate binding

Biological Process: cell-cell adhesion; cell-matrix adhesion; endocytosis; inflammatory response
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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