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anti-SIGMAR1 antibody :: SIGMAR1 Antibody

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Catalog # MBS8501188
Unit / Price
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  0.1 mg  /  $310 +1 FREE 8GB USB
Western blot
Product Name

SIGMAR1, Antibody

Popular Item
Full Product Name

SIGMAR1 Antibody

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
601978
3D Structure
ModBase 3D Structure for Q99720
Other Notes
Small volumes of anti-SIGMAR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western blot of anti-SIGMAR1 antibody
Western blot analysis of extracts of various celllines, using SIGMAR1 antibody.
anti-SIGMAR1 antibody Western blot image
NCBI/Uniprot data below describe general gene information for SIGMAR1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,013 Da
NCBI Official Full Name
sigma non-opioid intracellular receptor 1 isoform 6
NCBI Official Synonym Full Names
sigma non-opioid intracellular receptor 1
NCBI Official Symbol
SIGMAR1  [Similar Products]
NCBI Official Synonym Symbols
SRBP; ALS16; DSMA2; OPRS1; SR-BP; SIG-1R; SR-BP1; sigma1R; hSigmaR1
  [Similar Products]
NCBI Protein Information
sigma non-opioid intracellular receptor 1
UniProt Protein Name
Sigma non-opioid intracellular receptor 1
UniProt Synonym Protein Names
Aging-associated gene 8 protein; SR31747-binding protein; SR-BP; Sigma 1-type opioid receptor; SIG-1R; Sigma1-receptor; Sigma1R; hSigmaR1
UniProt Gene Name
SIGMAR1  [Similar Products]
UniProt Synonym Gene Names
OPRS1; SRBP; SR-BP; SIG-1R; Sigma1-receptor; Sigma1R; hSigmaR1  [Similar Products]
NCBI Summary for SIGMAR1
This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2013]
UniProt Comments for SIGMAR1
Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (PubMed:16472803, PubMed:9341151). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria ().
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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