NP_057623
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
41 kDa (375 aa), confirmed by MALDI-TOF.
NCBI Official Full Name
NAD-dependent protein deacetylase sirtuin-6 isoform 1
NCBI Official Synonym Full Names
sirtuin 6
NCBI Official Synonym Symbols
NCBI Protein Information
NAD-dependent protein deacetylase sirtuin-6
UniProt Protein Name
NAD-dependent protein deacetylase sirtuin-6
UniProt Synonym Protein Names
Regulatory protein SIR2 homolog 6; SIR2-like protein 6
UniProt Synonym Gene Names
NCBI Summary for SIRT6
This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
UniProt Comments for SIRT6
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD+ in the absence of acetylated substrate.
Product References and Citations for SIRT6 recombinant protein
Michishita E., et al. (2008) Nature. 452 (7186):492-6.; Mostoslavsky R., et al. (2006) Cell. 124 (2):315-29.;
Research Articles on SIRT6
Precautions
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Disclaimer
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Products associated with SIRT6 recombinant protein
Pathways associated with SIRT6 recombinant protein
Diseases associated with SIRT6 recombinant protein
Organs/Tissues associated with SIRT6 recombinant protein
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