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SIVA1 recombinant protein :: Apoptosis regulatory protein Siva Recombinant Protein

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Catalog # MBS1132006
Unit / Price
  0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
  0.01 mg (Yeast)  /  $110 +1 FREE 8GB USB
  0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $190 +1 FREE 8GB USB
  0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
  0.1 mg (Yeast)  /  $285 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $460 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $750 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $825 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,040 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,065 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
  1 mg (Yeast)  /  $1,180 +1 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $1,510 +1 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $1,630 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $2,025 +2 FREE 8GB USB
SDS-Page
Product Name

Apoptosis regulatory protein Siva (SIVA1), Recombinant Protein

Also Known As

Recombinant Human Apoptosis regulatory protein Siva

Product Synonym Names
CD27-binding protein; CD27BP
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-110aa; Full Length of Isoform 2
Sequence Length
175
Sequence
MPKRSCPFAD VAPLQLKVRV SQRELSRGVC AERYSQEVFD PSGVASIACS SCVRAVDGKA VCGQCERALC GQCVRTCWGC GSVACTLCGL VDCSDMYEKV LCTSCAMFET
OMIM
605567
3D Structure
ModBase 3D Structure for O15304
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater than 90% as determined by SDS-PAGE. (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of SIVA1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
SIVA1 recombinant protein
Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
Product Categories/Family for SIVA1 recombinant protein

SIVA1 recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
NCBI/Uniprot data below describe general gene information for SIVA1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27.8kD
NCBI Official Full Name
apoptosis regulatory protein Siva isoform 1
NCBI Official Synonym Full Names
SIVA1 apoptosis inducing factor
NCBI Official Symbol
SIVA1  [Similar Products]
NCBI Official Synonym Symbols
SIVA; CD27BP; Siva-1; Siva-2
  [Similar Products]
NCBI Protein Information
apoptosis regulatory protein Siva
UniProt Protein Name
Apoptosis regulatory protein Siva
UniProt Synonym Protein Names
CD27-binding protein; CD27BP
UniProt Gene Name
SIVA1  [Similar Products]
UniProt Synonym Gene Names
SIVA; CD27BP  [Similar Products]
UniProt Entry Name
SIVA_HUMAN
NCBI Summary for SIVA1
This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for SIVA1
Siva: a proapoptotic protein. Associates with CD27, a member of the tumor necrosis factor receptor family. Two alternatively spliced isoforms have been described. Isoform 1 but not isoform 2 may induce TNFRSF7/CD27 mediated apoptosis. Isoform 1 inhibits Bcl-xL anti-apoptotic activity.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 14q32.33

Cellular Component: cytoplasm; mitochondrion; nucleoplasm

Molecular Function: CD27 receptor binding; metal ion binding; protein binding; viral receptor activity; zinc ion binding

Biological Process: activated T cell apoptosis; entry of virus into host cell; inhibition of NF-kappaB transcription factor
Product References and Citations for SIVA1 recombinant protein
CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein.Prasad K.V.S., Ao Z., Yoon Y., Wu M.X., Rizk M., Jacquot S., Schlossman S.F.Proc. Natl. Acad. Sci. U.S.A. 94:6346-6351(1997) Characterization of TPA-responsive genes in U937 cells using ordered differential display PCR.Kang H.S., Park Y.J., Jung H.M., Jun D.Y., Huh T.L., Kim Y.H. Apoptosis in coxsackievirus B3-caused diseases interaction between the capsid protein VP2 and the proapoptotic protein siva.Henke A., Launhardt H., Klement K., Stelzner A., Zell R., Munder T.J. Virol. 74:4284-4290(2000) The ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress.Cao C., Ren X., Kharbanda S., Koleske A., Prasad K.V.S., Kufe D.J. Biol. Chem. 276:11465-11468(2001) The apoptotic capability of coxsackievirus B3 is influenced by the efficient interaction between the capsid protein VP2 and the proapoptotic host protein Siva.Henke A., Nestler M., Strunze S., Saluz H.-P., Hortschansky P., Menzel B., Martin U., Zell R., Stelzner A., Munder T.Virology 289:15-22(2001) Siva-1 binds to and inhibits BCL-X(L) -mediated protection against UV radiation-induced apoptosis.Xue L., Chu F., Cheng Y., Sun X., Borthakur A., Ramarao M., Pandey P., Wu M., Schlossman S.F., Prasad K.V.S.Proc. Natl. Acad. Sci. U.S.A. 99:6925-6930(2002) The Siva-1 putative amphipathic helical region (SAH) is sufficient to bind to BCL-XL and sensitize cells to UV radiation induced apoptosis.Chu F., Borthakur A., Sun X., Barkinge J., Gudi R., Hawkins S., Prasad K.V.S.Apoptosis 9:83-95(2004) Siva-1 and an alternative splice form lacking the death domain, Siva-2, similarly induce apoptosis in T lymphocytes via a caspase-dependent mitochondrial pathway.Py B., Slomianny C., Auberger P., Petit P.X., Benichou S.J. Immunol. 172:4008-4017(2004) Expression of Siva-1 protein or its putative amphipathic helical region enhances cisplatin-induced apoptosis in breast cancer cells effect of elevated levels of BCL-2.Chu F., Barkinge J., Hawkins S., Gudi R., Salgia R., Kanteti P.V.S.Cancer Res. 65:5301-5309(2005) The zinc containing pro-apoptotic protein siva interacts with the peroxisomal membrane protein pmp22.Nestler M., Martin U., Hortschansky P., Saluz H.-P., Henke A., Munder T.Mol. Cell. Biochem. 287:147-155(2006) Siva-1 negatively regulates NF-kappaB activity effect on T-cell receptor-mediated activation-induced cell death (AICD) .Gudi R., Barkinge J., Hawkins S., Chu F., Manicassamy S., Sun Z., Duke-Cohan J.S., Prasad K.V.S.Oncogene 25:3458-3462(2006) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.J. Proteomics 96:253-262(2014)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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