CAA06653.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
14,646 Da
NCBI Official Full Name
secondary lymphoid tissue chemokine
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 21
NCBI Official Synonym Symbols
ECL; SLC; CKb9; TCA4; 6Ckine; SCYA21 [Similar Products]
NCBI Protein Information
C-C motif chemokine 21; Efficient Chemoattractant for Lymphocytes; beta chemokine exodus-2; secondary lymphoid tissue chemokine; small inducible cytokine subfamily A (Cys-Cys), member 21
UniProt Protein Name
C-C motif chemokine 21
UniProt Synonym Protein Names
6Ckine; Beta-chemokine exodus-2; Secondary lymphoid-tissue chemokine; SLC; Small-inducible cytokine A21
UniProt Synonym Gene Names
UniProt Entry Name
CCL21_HUMAN
NCBI Summary for SLC
This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). [provided by RefSeq, Sep 2014]
UniProt Comments for SLC
CCL21: Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Belongs to the intercrine beta (chemokine CC) family.
Protein type: Motility/polarity/chemotaxis; Chemokine; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 9p13
Cellular Component: extracellular space; extracellular region
Molecular Function: chemokine activity; chemokine receptor binding; CCR7 chemokine receptor binding
Biological Process: positive regulation of filopodium formation; positive regulation of I-kappaB kinase/NF-kappaB cascade; formation of immunological synapse; positive regulation of chemotaxis; positive regulation of dendritic cell antigen processing and presentation; cell maturation; positive regulation of JNK cascade; positive regulation of phosphoinositide 3-kinase activity; positive regulation of cell adhesion mediated by integrin; positive regulation of receptor-mediated endocytosis; positive regulation of protein kinase B signaling cascade; G-protein coupled receptor protein signaling pathway; positive regulation of pseudopodium formation; positive regulation of actin filament polymerization; cell-cell signaling; release of sequestered calcium ion into cytosol; positive regulation of protein kinase activity; T cell costimulation; ruffle organization and biogenesis; dendritic cell chemotaxis; immune response; establishment of T cell polarity; positive regulation of cell-matrix adhesion; inflammatory response
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Organs/Tissues associated with SLC elisa kit
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