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anti-SLC24A6 antibody :: Rabbit anti-Human SLC24A6 Antibody

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Catalog # MBS004052
Unit / Price
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  0.1 mL  /  $440 +1 FREE 8GB USB
  0.2 mL  /  $715 +1 FREE 8GB USB
Western Blot (WB)
Product Name

SLC24A6, Antibody

Popular Item
Full Product Name

Rabbit SLC24A6 Antibody

Product Synonym Names
FLJ22233; Na(+)/K(+)/Ca(2+) exchange protein 6; Na(+)/K(+)/Ca(2+)-exchange protein 6; NCKX6; NCKX6_HUMAN; NCLX; Slc24a6; Sodium/potassium/calcium exchanger; Sodium/potassium/calcium exchanger 6; Solute carrier family 24 (sodium/potassium/calcium exchanger) member 6; Solute carrier family 24 member 6
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 12; NC_000012.11 (113736571..113772925, complement). Location: 12q24.13
OMIM
609841
3D Structure
ModBase 3D Structure for Q6J4K2
Host
Rabbit
Species Reactivity
Human
Specificity
SLC24A6 Antibody detects endogenous levels of total SLC24A6
Purity/Purification
Immunogen affinity purified
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Buffer
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Immunogen
A synthesized peptide
Function
Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762, PubMed:22829870, PubMed:23056385, PubMed:24898248, PubMed:28219928). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (PubMed:23056385). Required for store-operated Ca2+ entry (SOCE) and Ca2+ release-activated Ca2+ (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (PubMed:28219928). Involved in B-lymphocyte chemotaxis (By similarity). Able to transport Ca2+ in exchange of either Li+ or Na+, explaining how Li+ catalyzes Ca2+ exchange (PubMed:15060069). In contrast to other members of the family its function is independent of K+ (PubMed:15060069).
Preparation and Storage
Store at -20 °C.Stable for 12 months from date of receipt
Other Notes
Small volumes of anti-SLC24A6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Application Notes for anti-SLC24A6 antibody
WB 1:500~1:1000
ELISA(peptide) 1:20000-1:40000

Optimal dilutions/concentrations should be determined by the end user.

Western Blot (WB) of anti-SLC24A6 antibody
Western Blot analysis of extracts from MCF-7 cells using SLC24A6 antibody.
anti-SLC24A6 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for SLC24A6. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
sodium/potassium/calcium exchanger 6, mitochondrial
NCBI Official Synonym Full Names
solute carrier family 24 (sodium/lithium/calcium exchanger), member 6
NCBI Official Symbol
SLC24A6  [Similar Products]
NCBI Official Synonym Symbols
NCLX; NCKX6
  [Similar Products]
NCBI Protein Information
sodium/potassium/calcium exchanger 6, mitochondrial; solute carrier family 24 member 6; Na(+)/K(+)/Ca(2+)-exchange protein 6; sodium/calcium exchanger protein, mitochondrial; solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
UniProt Protein Name
Sodium/potassium/calcium exchanger 6, mitochondrial
UniProt Synonym Protein Names
Na(+)/K(+)/Ca(2+)-exchange protein 6; Sodium/calcium exchanger protein, mitochondrial; Solute carrier family 24 member 6
UniProt Gene Name
SLC24A6  [Similar Products]
UniProt Synonym Gene Names
NCKX6; NCLX  [Similar Products]
UniProt Entry Name
NCKX6_HUMAN
NCBI Summary for SLC24A6
SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion (Cai and Lytton, 2004 [PubMed 14625281]).[supplied by OMIM, Mar 2008]
UniProt Comments for SLC24A6
SLC24A6: Transports Ca(2+) in exchange for either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange. In contrast to other members of the family its function is independent of K(+). Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum; Membrane protein, multi-pass; Transporter, SLC family; Transporter; Membrane protein, integral; Calcium-binding

Chromosomal Location of Human Ortholog: 12q24.13

Cellular Component: mitochondrial crista; plasma membrane; sarcolemma

Molecular Function: protein homodimerization activity; calcium:sodium antiporter activity

Biological Process: mitochondrial calcium ion homeostasis; cytosolic calcium ion homeostasis; response to stimulus; ion transport; glucose homeostasis; regulation of insulin secretion; transmembrane transport; mitochondrial calcium ion transport
Research Articles on SLC24A6
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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