NP_113924.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
70,694 Da
NCBI Official Full Name
very long-chain acyl-CoA synthetase
NCBI Official Synonym Full Names
solute carrier family 27 (fatty acid transporter), member 2
NCBI Protein Information
very long-chain acyl-CoA synthetase; VLCS; VLACS; FATP-2; THCA-CoA ligase; fatty acid transport protein 2; long-chain-fatty-acid--CoA ligase; solute carrier family 27 member 2; very long-chain-fatty-acid-CoA ligase; fatty-acid-coenzyme A ligase, very long-chain 1; solute carrier family 27 (fatty acid transporter), member 32
UniProt Protein Name
Very long-chain acyl-CoA synthetase
UniProt Synonym Protein Names
Fatty acid transport protein 2; FATP-2; Fatty-acid-coenzyme A ligase, very long-chain 1; Long-chain-fatty-acid--CoA ligase (EC:6.2.1.3); Solute carrier family 27 member 2; THCA-CoA ligase; Very long-chain-fatty-acid-CoA ligase
UniProt Synonym Gene Names
UniProt Entry Name
S27A2_RAT
NCBI Summary for SLC27A2
has very long-chain acyl-CoA synthetase activity; may play a role in fatty acid metabolism [RGD, Feb 2006]
UniProt Comments for SLC27A2
SLC27A2: Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity)
Protein type: Membrane protein, multi-pass; Ligase; EC 6.2.1.3; Membrane protein, integral
Cellular Component: peroxisomal membrane; endoplasmic reticulum membrane; integral to peroxisomal membrane; intracellular membrane-bound organelle; mitochondrion; endoplasmic reticulum; endoplasmic reticulum lumen; integral to membrane; integral to endoplasmic reticulum membrane; peroxisome
Molecular Function: protein binding; enzyme binding; fatty acid transporter activity; very-long-chain-fatty-acid-CoA ligase activity; phytanate-CoA ligase activity; ATP binding; receptor binding; long-chain-fatty-acid-CoA ligase activity
Biological Process: bile acid biosynthetic process; fatty acid beta-oxidation; very-long-chain fatty acid catabolic process; very-long-chain fatty acid metabolic process; long-chain fatty acid metabolic process; fatty acid transport; fatty acid alpha-oxidation
Research Articles on SLC27A2
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Pathways associated with SLC27A2 elisa kit
Diseases associated with SLC27A2 elisa kit
Organs/Tissues associated with SLC27A2 elisa kit
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