NP_003032.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49,357 Da
NCBI Official Full Name
sodium/glucose cotransporter 2
NCBI Official Synonym Full Names
solute carrier family 5 (sodium/glucose cotransporter), member 2
NCBI Official Synonym Symbols
NCBI Protein Information
sodium/glucose cotransporter 2
UniProt Protein Name
Sodium/glucose cotransporter 2
UniProt Synonym Protein Names
Low affinity sodium-glucose cotransporter; Solute carrier family 5 member 2
UniProt Synonym Gene Names
UniProt Entry Name
SC5A2_HUMAN
NCBI Summary for SLC5A2
This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. Two transcript variants, one protein-coding and one not, have been found for this gene. [provided by RefSeq, Feb 2015]
UniProt Comments for SLC5A2
SLC5A2: Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1. Defects in SLC5A2 are the cause of renal glucosuria (GLYS1). GLYS1 is an autosomal recessive disorder characterized by a normal fasting serum glucose concentration and persistent isolated glucosuria, with a normal glucose tolerance test. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, SLC family
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: plasma membrane; integral to membrane
Molecular Function: low-affinity glucose:sodium symporter activity
Biological Process: transport; sodium ion transport; carbohydrate metabolic process; glucose transport; transmembrane transport
Disease: Renal Glucosuria
Research Articles on SLC5A2
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Products associated with SLC5A2 sirna
Pathways associated with SLC5A2 sirna
Diseases associated with SLC5A2 sirna
Organs/Tissues associated with SLC5A2 sirna
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