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Smurf2 recombinant protein :: E3 ubiquitin-protein ligase SMURF2 (Smurf2) Recombinant Protein

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Catalog # MBS951177
Unit / Price
  0.05 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,320 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,575 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $1,595 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,635 +2 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,675 +2 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,760 +2 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,850 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,360 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,390 +2 FREE 8GB USB
  1 mg (E-Coli)  /  $2,490 +3 FREE 8GB USB
  1 mg (Yeast)  /  $2,800 +3 FREE 8GB USB
  1 mg (Baculovirus)  /  $3,130 +3 FREE 8GB USB
Smurf2 recombinant protein
Product Name

E3 ubiquitin-protein ligase SMURF2 (Smurf2), Recombinant Protein

Also Known As

Recombinant Mouse E3 ubiquitin-protein ligase SMURF2 (Smurf2)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-748aa, Full length protein
Sequence Length
748
Sequence
MSNPGGRRNG PVKLRLTVLC AKNLVKKDFF RLPDPFAKVV VDGSGQCHST DTVKNTLDPK WNQHYDLYIG KSDSVTISVW NHKKIHKKQG AGFLGCVRLL SNAINRLKDT GYQRLDLCKL GPNDNDTVRG QIVVSLQSRD RIGTGGQVVD CSRLFDNDLP DGWEERRTAS GRIQYLNHIT RTTQWERPTR PASEYSSPGR PLSCFVDENT PITGTNGATC GHSSDPRLAE RRVRSQRHRN YMSRTHLHTP PDLPEGYEQR TTQQGQVYFL HTQTGVSTWH DPRVPRDLSN INCEELGPLP PGWEIRNTAT GRVYFVDHNN RTTQFTDPRL SANLHLVLNR QNQLKDQQQQ QVVPLCPDDT ECLTVPRYKR DLVQKLKILR QELSQQQPQA GHCRIEVSRE EIFEESYRQV MKMRPKDLWK RLMIKFRGEE GLDYGGVARE WLYLLSHEML NPYYGLFQYS RDDIYTLQIN PDSAVNPEHL SYFHFVGRIM GMAVFHGHYI DGGFTLPFYK QLLGKSITLD DMELVDPDLH NSLVWILEND ITGVLDHTFC VEHNAYGEII QHELKPNGKS IPVTEENKKE YVRLYVNWRF LRGIEAQFLA LQKGFNEVIP QHLLKTFDEK ELELIICGLG KIDVSDWKVN TRLKHCTPDS NVVKWFWKAV EFFDEERRAR LLQFVTGSSR VPLQGFKALQ GAAGPRLFTI HQIDACTNNL PKAHTCFNRI DIPPYESYEK LYEKLLTAIE ETCGFAVE
3D Structure
ModBase 3D Structure for A2A5Z6
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Mouse
Storage Buffer
Tris-based buffer, 50% glycerol
Tag Information
Tag type will be determined during the manufacturing process
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of Smurf2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Smurf2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
84,569 Da
NCBI Official Full Name
E3 ubiquitin-protein ligase SMURF2
NCBI Official Synonym Full Names
SMAD specific E3 ubiquitin protein ligase 2
NCBI Official Symbol
Smurf2  [Similar Products]
NCBI Official Synonym Symbols
AI558114; AI649275; 2810411E22Rik
  [Similar Products]
NCBI Protein Information
E3 ubiquitin-protein ligase SMURF2
UniProt Protein Name
E3 ubiquitin-protein ligase SMURF2
UniProt Synonym Protein Names
HECT-type E3 ubiquitin transferase SMURF2; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2
UniProt Gene Name
Smurf2  [Similar Products]
UniProt Comments for Smurf2
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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