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SNAP23 recombinant protein :: Synaptosomal-associated protein Recombinant Protein

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Catalog # MBS143876
Unit / Price
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  0.005 mg  /  $140 +1 FREE 8GB USB
  0.025 mg  /  $205 +1 FREE 8GB USB
  1 mg  /  $2,800 +3 FREE 8GB USB
SNAP23 recombinant protein
Product Name

Synaptosomal-associated protein (SNAP23), Recombinant Protein

Full Product Name

Recombinant Human Synaptosomal-associated protein 23kDa

Product Synonym Names
SNAP23 Human; Synaptosomal-associated protein 23 Human Recombinant; SNAP23A; SNAP23B; HsT17016; Synaptosomal-associated protein 23; Vesicle-membrane fusion protein SNAP-23; SNAP23
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MDNLSSEEIQ QRAHQITDES LESTRRILGL AIESQDAGIK TITMLDEQKE QLNRIEEGLD QINKDMRETE KTLTELNKCC GLCVCPCNRT KNFESGKAYK TTWGDGGENS PCNVVSKQPG PVTNGQLQQP TTGAASGGYI KRITNDARED EMEENLTQVG SILGNLKDMA LNIGNEIDAQ NPQIKRITDK ADTNRDRIDI ANARAKKLID S
OMIM
602534
3D Structure
ModBase 3D Structure for O00161
Host
E Coli
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Form/Format
The protein solution contains 20mM Tris-HCl pH-8.
Sterile Filtered colorless solution.
Other Notes
Small volumes of SNAP23 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
SNAP23 recombinant protein
Description: SNAP23 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 211 amino acids and having a molecular mass of 23.3 kDa.

Introduction: SNAP23 is a non-neuronal SNAP25 protein homologue and a target SNARE ubiquitously expressed on the plasma membrane and other intracellular membranes. SNAP23 is involved in exocytotic membrane fusion in most cells that do not express SNAP-25. SNAP23 is an essential component of the high affinity receptor for the general membrane fusion machinery and an crucial regulator of transport vesicle docking and fusion. SNAP23 is phosphorylated in platelets through cell activation during a protein kinase C-related mechanism at two or more sites. SNAP23, the ubiqitously expressed homologue of SNAP25, interacts directly with ubiquitous kinesin heavy chain (uKHC). SNAP-23 is expressed in human eosinophils and is a candidates for association with VAMP-2 during docking, which is followed by exocytosis.
NCBI/Uniprot data below describe general gene information for SNAP23. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,789 Da
NCBI Official Full Name
synaptosomal-associated protein 23 isoform SNAP23A
NCBI Official Synonym Full Names
synaptosomal-associated protein, 23kDa
NCBI Official Symbol
SNAP23  [Similar Products]
NCBI Official Synonym Symbols
SNAP-23; SNAP23A; SNAP23B; HsT17016
  [Similar Products]
NCBI Protein Information
synaptosomal-associated protein 23; synaptosomal-associated protein, 23kD; vesicle-membrane fusion protein SNAP-23
UniProt Protein Name
Synaptosomal-associated protein 23
UniProt Synonym Protein Names
Vesicle-membrane fusion protein SNAP-23
UniProt Gene Name
SNAP23  [Similar Products]
UniProt Synonym Gene Names
SNAP-23  [Similar Products]
UniProt Entry Name
SNP23_HUMAN
NCBI Summary for SNAP23
Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for SNAP23
SNAP23: a member of the SNAP-25 family of SNARE proteins. Structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternatively spliced isoforms have been described.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 15q14

Cellular Component: nucleoplasm; SNARE complex; specific granule; azurophil granule; neuron projection; mast cell granule; focal adhesion; cytoplasm; plasma membrane; synapse

Molecular Function: SNAP receptor activity; protein binding; syntaxin binding

Biological Process: synaptic vesicle fusion to presynaptic membrane; protein transport; histamine secretion by mast cell; vesicle targeting; post-Golgi vesicle-mediated transport; synaptic vesicle priming
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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