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SNCB recombinant protein :: beta-Synuclein Recombinant Protein

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Catalog # MBS203010
Unit / Price
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  0.1 mg  /  $255 +1 FREE 8GB USB
  0.5 mg  /  $535 +1 FREE 8GB USB
SDS-Page
Product Name

beta-Synuclein (SNCB), Recombinant Protein

Full Product Name

beta-Synuclein, 1-134aa, Human, E Coli

Product Synonym Names
Beta-synuclein; SNCB beta-Synuclein; B-synuclein; Beta synuclein; beta synuclein; Phosphoneuroprotein 14; PNP14; Synuclein beta
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQ GVASVAEKTK EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKPEEVAQ EAAEEPLIEP LMEPEGESYE DPPQEEYQEY EPEA
OMIM
S69965 mRNA
3D Structure
ModBase 3D Structure for Q16143
Host
E Coli
Purity/Purification
> 95% by SDS-PAGE
Form/Format
Liquid. In 20 mM Tris-HCl Buffer (pH 7.5) containing 0.1 M NaCl, 1mM MgCl2
Concentration
1 mg/ml (determined by BCA assay) (lot specific)
Antigen Species
Human
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Other Notes
Small volumes of SNCB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
SNCB recombinant protein
beta-synuclein (amino acids 1-134), an acidic neuronal protein of 134 amino acids, is extremely heat-resistant. beta-synucelin also has a chaperone-like activity. Recently, beta-synuclein has been suggested to inhibit
Product Categories/Family for SNCB recombinant protein
Applications Tested/Suitable for SNCB recombinant protein
SDS-PAGE

NCBI/Uniprot data below describe general gene information for SNCB. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
14.2 kDa (134 aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)[Similar Products]
NCBI Official Full Name
beta-synuclein isoform 1
NCBI Official Synonym Full Names
synuclein beta
NCBI Official Symbol
NCBI Protein Information
beta-synuclein
UniProt Protein Name
Beta-synuclein
Protein Family
UniProt Gene Name
NCBI Summary for SNCB
This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
UniProt Comments for SNCB
Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
Product References and Citations for SNCB recombinant protein
Jakes R., et al. (1994) FEBS lett. 345, 27-32.; Kim J.,et al. (1997) Molecules and Cells. 7, 78-83.; Hashimoto M., et al. (2001) Neuron 32, 213-223.;

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with SNCB recombinant protein
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