NP_001001502.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
14.2 kDa (134 aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher) [Similar Products]
NCBI Official Full Name
beta-synuclein isoform 1
NCBI Official Synonym Full Names
synuclein beta
NCBI Protein Information
beta-synuclein
UniProt Protein Name
Beta-synuclein
NCBI Summary for SNCB
This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
UniProt Comments for SNCB
Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
Product References and Citations for SNCB recombinant proteinJakes R., et al. (1994) FEBS lett. 345, 27-32.; Kim J.,et al. (1997) Molecules and Cells. 7, 78-83.; Hashimoto M., et al. (2001) Neuron 32, 213-223.;
Research Articles on SNCB
Precautions
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Products associated withSNCB recombinant protein
Diseases associated with SNCB recombinant protein
Organs/Tissues associated with SNCB recombinant protein
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