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SNuPN recombinant protein

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Catalog # MBS203669
Unit / Price
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  0.1 mg  /  $310 +1 FREE 8GB USB
  0.5 mg  /  $720 +1 FREE 8GB USB
SDS-Page
Product Name

SNuPN, Recombinant Protein

Popular Item
Full Product Name

SNuPN, 1-360aa, Human, His tag, E Coli

Product Synonym Names
Snurportin1; KPNBL; RNuT1; Snurportin1; SPN1; Snurportin1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MGSSHHHHHH SSGLVPRGSH MEELSQALAS SFSVSQDLNS TAAPHPRLSQ YKSKYSSLEQ SERRRRLLEL QKSKRLDYVN HARRLAEDDW TGMESEEENK KDDEEMDIDT VKKLPKHYAN QLMLSEWLID VPSDLGQEWI VVVCPVGKRA LIVASRGSTS AYTKSGYCVN RFSSLLPGGN RRNSTAKDYT ILDCIYNEVN QTYYVLDVMC WRGHPFYDCQ TDFRFYWMHS KLPEEEGLGE KTKLNPFKFV GLKNFPCTPE SLCDVLSMDF PFEVDGLLFY HKQTHYSPGS TPLVGWLRPY MVSDVLGVAV PAGPLTTKPD YAGHQLQQIM EHKKSQKEGM KEKLTHKASE NGHYELEHLS TPKLKGSSHS PDHPGCLMEN
OMIM
AF039029 mRNA
3D Structure
ModBase 3D Structure for O95149
Host
E Coli
Purity/Purification
> 90% by SDS-PAGE
Form/Format
Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol 0.1M NaCl
Concentration
1.0 mg/ml (determined by Bradford assay) (lot specific)
Antigen Species
Human
Tag Information
His-tag
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Other Notes
Small volumes of SNuPN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for SNuPNpurchase
Transcript factor proteins are classical examples of human proteins which reside in cytoplasm and require transporter 1 to move to DNA in the nucleus. SNuPN - human snurportin 1 - has emerged as a critical RNA transporter regulating gene and protein expression. Drugs compounds and vector virus screens have begun to unravel human mouse rat SNuPN (KPNBL rNUT1) functions. References and SNuPN gene information is found in PubMed ID searches. Determination of more information about possible pathways interactions products proteins for the RNA transporter 1 SNuPN will be aided with a HIS tag SNuPN recombinant human product. Our custom protein production service is considered #1. SNuPN recombinant protein is expressed in E coli mammalian cell free kit and purified by methods similar to other recombinant human proteins in MyBiosource services section of our catalog. Use our Creative Biomart produced protein recombinant to produce antibodies for ELISA assay today.
Related Product Information for
SNuPN recombinant protein
SNuPN, also known as KPNBL or RNuT1, is a nuclear import adaptor protein belonging to the Snurportin family. Localizing to the cytoplasm and nucleus, Snurportin-1 contains an N-terminal IBB domain and a trimethylguanosine (m3G)-cap binding domain. It specifically binds the terminal 2,2,7-m3G-cap at the 5' end of u snRNPs and functions to transport u snRNPs into the nucleus via an association with Importin beta. Recombinant human Snurportin-1 protien, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
Product Categories/Family for SNuPN recombinant protein
Applications Tested/Suitable for SNuPN recombinant protein
SDS-PAGE

NCBI/Uniprot data below describe general gene information for SNuPN. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43.3 (380aa) confirmed by MALDI-TOF
NCBI Official Full Name
snurportin-1
NCBI Official Synonym Full Names
snurportin 1
NCBI Official Symbol
SNUPN  [Similar Products]
NCBI Official Synonym Symbols
KPNBL; RNUT1; Snurportin1
  [Similar Products]
NCBI Protein Information
snurportin-1
UniProt Protein Name
Snurportin-1
UniProt Synonym Protein Names
RNA U transporter 1
UniProt Gene Name
SNUPN  [Similar Products]
UniProt Synonym Gene Names
RNUT1; SPN1  [Similar Products]
NCBI Summary for SNuPN
The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for SNuPN
Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
Product References and Citations for SNuPN recombinant protein
Huber J., et al. (1998) EMBO J. 17 (14):4114-26.

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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