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SNX1 cdna clone

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Catalog # MBS1275849
Unit / Price
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  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
SNX1 cdna clone
Product Name

SNX1, cDNA Clone

Popular Item
Full Product Name

SNX1 cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggcgtcgg gtggtggtgg ctgtagcgct tcggagagac tgcctccgcc cttccccggc ctggagccgg agtccgaggg ggcggccggg ggatcagaac ccgaggctgg ggacagcgac accgaggggg aggacatttt caccggcgcc gcggtggtca gtaaacatca gtctccaaag ataactacat cccttcttcc catcaacaat ggctccaaag aaaatgggat ccatgaagaa caagaccaag agccacagga tctctttgca gatgccacag tggagctatc cttggacagc acacaaaata atcagaagaa ggtgctagcc aaaacactca tttctcttcc tcctcaggaa gccacaaatt cttcgaagcc ccagccaacc tatgaggagc tagaggaaga agaacaggag gatcaatttg atttgacagt cggtataact gatcctgaga agatagggga tggtatgaat gcatatgtag cctacaaagt tacaacacag acaagcttac cattgttcag aagcaaacag tttgcagtaa aaagaagatt tagtgacttt ctgggtcttt atgagaagct ttccgagaag cactctcaga atggcttcat tgtccctcca cccccggaga agagcctcat agggatgaca aaagtgaaag ttgggaagga agattcttct tctgcagaat ttcttgaaaa acggagggcc gctttagaaa ggtaccttca gaggattgta aatcatccta ccatgttaca ggaccctgac gtcagagagt tcttggaaaa agaagagctg ccacgtgccg tgggtaccca gacattgagt ggtgctggtc tcctcaagat gttcaacaaa gccacagatg ccgtcagcaa aatgaccatc aagatgaatg aatcagacat ttggtttgag gagaagctcc aggaggtaga gtgtgaggag cagcgcttac ggaaactgca tgctgttgta gaaactctag tcaaccatag gaaagagcta gcgctgaaca cagcccagtt tgcaaagagt ctagccatgc ttgggagctc tgaggacaac acggcattgt cacgggcact ctcccagctg gctgaggtgg aagaaaaaat tgagcagctc caccaggaac aggccaacaa tgacttcttc ctccttgctg agctcctgag tgactacatt cgcctcctgg ccatagtccg cgctgccttc gaccagcgca tgaagacatg gcagcgctgg caggatgccc aagccacact gcagaagaag cgggaggccg aggctcggct gctgtgggcc aacaagcctg ataagctgca gcaggccaag gacgagatcc tcgagtggga gtctcgggtg actcaatatg aaagggactt cgagaggatt tcaacagtgg tccgaaaaga agtgatacgg tttgagaaag agaaatccaa ggacttcaag aaccacgtga tcaagtacct tgagacactc ctttactcac agcagcagct ggcaaagtac tgggaagcct tccttcctga ggcaaaggcc atctcctaa
OMIM
601272
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of SNX1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for SNX1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
63,082 Da
NCBI Official Full Name
Homo sapiens sorting nexin 1, mRNA
NCBI Official Synonym Full Names
sorting nexin 1
NCBI Official Symbol
NCBI Official Synonym Symbols
VPS5; HsT17379
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NCBI Protein Information
sorting nexin-1
UniProt Protein Name
Sorting nexin-1
Protein Family
UniProt Gene Name
UniProt Entry Name
SNX1_HUMAN
NCBI Summary for SNX1
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for SNX1
SNX1: May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Belongs to the sorting nexin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 15q22.31

Cellular Component: cell-cell adherens junction; cytoplasm; early endosome membrane; endosome membrane; extrinsic to membrane; intracellular membrane-bound organelle; membrane; protein complex; retromer complex; vesicle

Molecular Function: epidermal growth factor receptor binding; identical protein binding; insulin receptor binding; phosphoinositide binding; protein binding; protein heterodimerization activity; protein homodimerization activity

Biological Process: intracellular protein transport; receptor internalization; retrograde transport, endosome to Golgi; vesicle organization and biogenesis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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