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anti-SORL1 antibody :: Mouse anti-Human SORL1 Antibody

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Catalog # MBS850606
Unit / Price
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  0.1 mg  /  $290 +1 FREE 8GB USB
Western Blot (WB)
Product Name

SORL1, Antibody

Full Product Name

SORL1 Antibody

Product Synonym Names
SORL1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
104300
3D Structure
ModBase 3D Structure for Q92673
Isotype
IgG
Clone Number
7D7B11
Host
Mouse
Species Reactivity
Human
Form/Format
Ascitic fluid containing 0.03% sodium azide.
Immunogen
Purified recombinant fragment of SORL1 (aa2159-2214) expressed in E. Coli.
Preparation and Storage
Store at 4 degree C, for long term storage, store at-20 degree C
Other Notes
Small volumes of anti-SORL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SORL1 antibody
SORL1 (sortilin-related receptor, L A repeats containing) also known as sorting protein-related receptor containing LDLR class A (SorLA), is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP (receptor-associated protein). SorLA is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous SorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function. The gene encoding for the protein maps to chromosome 8p23.1. SorLA is expressed mainly in brain (cerebral cortex, cerebellum and the occipital pole), but can also be found in liver, spinal cord, kidney, testis and pancreas.
Applications Tested/Suitable for anti-SORL1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-SORL1 antibody
WB: 1:500-1:2000
ELISA: 1:10000

Western Blot (WB) of anti-SORL1 antibody
Figure 1. Western blot analysis using SORL1 mouse mAb against truncated SORL1 recombinant protein (1) and SORL1 (aa2159-2214)-hIgGFc transfected CHO-K1 cell lysate (2).
anti-SORL1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for SORL1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
248,426 Da
NCBI Official Full Name
sortilin-related receptor preproprotein
NCBI Official Synonym Full Names
sortilin related receptor 1
NCBI Official Symbol
SORL1  [Similar Products]
NCBI Official Synonym Symbols
LR11; LRP9; SORLA; gp250; SorLA-1; C11orf32
  [Similar Products]
NCBI Protein Information
sortilin-related receptor
UniProt Protein Name
Sortilin-related receptor
UniProt Synonym Protein Names
Low-density lipoprotein receptor relative with 11 ligand-binding repeats; LDLR relative with 11 ligand-binding repeats; LR11; SorLA-1; Sorting protein-related receptor containing LDLR class A repeats; SorLA
Protein Family
UniProt Gene Name
SORL1  [Similar Products]
UniProt Synonym Gene Names
C11orf32; LDLR relative with 11 ligand-binding repeats; LR11; SorLA  [Similar Products]
NCBI Summary for SORL1
This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded preproprotein is proteolytically processed to generate the mature receptor, which likely plays roles in endocytosis and sorting. Mutations in this gene may be associated with Alzheimer's disease. [provided by RefSeq, Feb 2016]
UniProt Comments for SORL1
Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. Involved in APP trafficking to and from the Golgi apparatus. It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta, thereby reducing the burden of amyloidogenic peptide formation. Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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