NP_001258528.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
91,200 Da
NCBI Official Full Name
sortilin isoform 1
NCBI Official Synonym Full Names
sortilin 1
NCBI Official Synonym Symbols
Ntr3; Ntsr3; AI852375; 2900053A11Rik [Similar Products]
NCBI Protein Information
sortilin; mNTR3; neurotensin receptor 3
UniProt Protein Name
Sortilin
UniProt Synonym Protein Names
Neurotensin receptor 3; NTR3; mNTR3
UniProt Synonym Gene Names
UniProt Entry Name
SORT_MOUSE
UniProt Comments for SORT1
SORT1: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. A common polymorphism located in a non-coding region between CELSR2 and PSRC1 alters a CEBP transcription factor binding site and is responsible for changes in hepatic expression of SORT1. Altered SORT1 expression in liver affects low density lipoprotein cholesterol levels in plasma and is associated with susceptibility to myocardial infarction. Belongs to the VPS10-related sortilin family. SORT1 subfamily.
Protein type: Membrane protein, integral; Receptor, misc.
Cellular Component: Golgi apparatus; cell surface; intracellular membrane-bound organelle; clathrin-coated vesicle; endoplasmic reticulum; lysosome; early endosome; dendrite; cytoplasmic membrane-bound vesicle; integral to membrane; coated pit; trans-Golgi network transport vesicle; membrane; cell soma; perinuclear region of cytoplasm; plasma membrane; nucleus; endosome
Molecular Function: protein binding; enzyme binding; nerve growth factor receptor activity; nerve growth factor binding; neurotensin receptor activity, non-G-protein coupled
Biological Process: ossification; nerve growth factor receptor signaling pathway; endosome transport via multivesicular body sorting pathway; multicellular organismal development; vesicle organization and biogenesis; Golgi to endosome transport; myotube differentiation; endocytosis; response to insulin stimulus; G-protein coupled receptor protein signaling pathway; induction of apoptosis via death domain receptors; neuropeptide signaling pathway; regulation of gene expression; transport; glucose import; endosome to lysosome transport; plasma membrane to endosome transport; negative regulation of lipoprotein lipase activity; cell differentiation
Research Articles on SORT1
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Pathways associated with SORT1 elisa kit
Diseases associated with SORT1 elisa kit
Organs/Tissues associated with SORT1 elisa kit
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