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SOSTDC1 recombinant protein :: Sclerostin Domain Containing 1 Recombinant Protein

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Catalog # MBS142980
Unit / Price
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  0.005 mg  /  $140 +1 FREE 8GB USB
  0.02 mg  /  $205 +1 FREE 8GB USB
  1 mg  /  $2,665 +3 FREE 8GB USB
SOSTDC1 recombinant protein
Product Name

Sclerostin Domain Containing 1 (SOSTDC1), Recombinant Protein

Full Product Name

Recombinant Human Sclerostin Domain Containing 1

Product Synonym Names
SOSTDC1 Human; Sclerostin Domain Containing 1 Human Recombinant; Sclerostin domain-containing protein 1; Ectodermal BMP inhibitor; Ectodin; Uterine sensitization-associated gene 1 protein; USAG-1; SOSTDC1; USAG1; CDA019
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MGSSHHH HHH SSGLVPRGSH MGSFKN DATE ILYSHVVKPV PAHPSSNSTL NQARNGGRHF SNTGLDRNTR VQVGCRELRS TKYISDGQCT SISPLKELVC AGECLPLPVL PNWIGGGYGT KYWSRRSSQE WRCVNDKTRT QRIQLQCQDG STRTYKITVV TACKCKRYTR QHNESSHNFE SMSPAKPVQH HRERKRASKS SKHSMS.
OMIM
609675
3D Structure
ModBase 3D Structure for Q6X4U4
Host
E Coli
Purity/Purification
Greater than 85.0% as determined by SDS-PAGE.
Form/Format
SOSTDC1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol.
Sterile Filtered colorless solution.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Other Notes
Small volumes of SOSTDC1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
SOSTDC1 recombinant protein
Description: SOSTDC1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 206 amino acids (24-206 a.a) and having a molecular mass of 23kDa.SOSTDC1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: Sclerostin Domain Containing 1 (SOSTDC1) belongs to the sclerostin family and an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. The SOSTDC1 protein acts as a bone morphogenetic protein (BMP) antagonist. Specifically, SOSTDC1 directly associates with BMPs, prohibiting them from binding their receptors, thus regulating BMP signaling throughout cellular proliferation, differentiation, and programmed cell death. SOSTDC1 may also be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and hinders TGF-beta signaling. In addition, SOSTDC1 directly antagonizes the activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner.
NCBI/Uniprot data below describe general gene information for SOSTDC1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,260 Da
NCBI Official Full Name
sclerostin domain-containing protein 1
NCBI Official Synonym Full Names
sclerostin domain containing 1
NCBI Official Symbol
SOSTDC1  [Similar Products]
NCBI Official Synonym Symbols
USAG1; CDA019; ECTODIN
  [Similar Products]
NCBI Protein Information
sclerostin domain-containing protein 1; cystine-knot containing secreted protein; ectodermal BMP inhibitor; uterine sensitization-associated protein-1
UniProt Protein Name
Sclerostin domain-containing protein 1
UniProt Synonym Protein Names
Ectodermal BMP inhibitor; Ectodin; Uterine sensitization-associated gene 1 protein; USAG-1
UniProt Gene Name
SOSTDC1  [Similar Products]
UniProt Synonym Gene Names
USAG1; Ectodin; USAG-1  [Similar Products]
UniProt Entry Name
SOSD1_HUMAN
NCBI Summary for SOSTDC1
This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death. [provided by RefSeq, Jul 2008]
UniProt Comments for SOSTDC1
SOSTDC1: May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling. Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner. Belongs to the sclerostin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7p21.1

Cellular Component: extracellular space

Biological Process: hair follicle morphogenesis; Wnt receptor signaling pathway; pattern specification process; odontogenesis of dentine-containing teeth; negative regulation of BMP signaling pathway; negative regulation of cell fate commitment
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with SOSTDC1 recombinant protein
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