NP_955468.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
67,197 Da
NCBI Official Full Name
spastin isoform 2
NCBI Official Synonym Full Names
spastin
NCBI Protein Information
spastin; spastic paraplegia 4 protein; spastic paraplegia 4 (autosomal dominant; spastin)
UniProt Protein Name
Spastin
UniProt Synonym Protein Names
Spastic paraplegia 4 protein
UniProt Synonym Gene Names
UniProt Entry Name
SPAST_HUMAN
NCBI Summary for SPAST
This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The encoded ATPase may be involved in the assembly or function of nuclear protein complexes. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequences have not been determined. Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4. [provided by RefSeq, Jul 2008]
UniProt Comments for SPAST
spastin: ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. May also play a role in axon growth and the formation of axonal branches. Defects in SPAST are the cause of spastic paraplegia autosomal dominant type 4 (SPG4). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG4 is the most common form of autosomal dominant spastic paraplegias. Belongs to the AAA ATPase family. Spastin subfamily. 4 isoforms of the human protein are produced by alternative promoter.
Protein type: Membrane protein, integral; EC 3.6.4.3; Cytoskeletal
Chromosomal Location of Human Ortholog: 2p24-p21
Cellular Component: microtubule cytoskeleton; centrosome; microtubule; endoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm; integral to membrane; spindle; cytoplasmic vesicle; midbody; nucleus; endosome
Molecular Function: protein binding; microtubule binding; beta-tubulin binding; microtubule-severing ATPase activity; alpha-tubulin binding; ATP binding
Biological Process: positive regulation of microtubule depolymerization; ER to Golgi vesicle-mediated transport; axonogenesis; metabolic process; microtubule severing; microtubule bundle formation; protein homooligomerization; cytoplasmic microtubule organization and biogenesis
Disease: Spastic Paraplegia 4, Autosomal Dominant
Research Articles on SPAST
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Products associated with SPAST elisa kit
Diseases associated with SPAST elisa kit
Organs/Tissues associated with SPAST elisa kit
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