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SPDEF cdna clone

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Catalog # MBS1278768
Unit / Price
  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
SPDEF cdna clone
Product Name

SPDEF, cDNA Clone

Popular Item
Also Known As

SPDEF cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
1008
Sequence
atgggcagcg ccagcccggg tctgagcagc gtatccccca gccacctcct gctgcccccc gacacggtgt cgcggacagg cttggagaag gcggcagcgg gggcagtggg tctcgagaga cgggactgga gtcccagtcc acccgccacg cccgagcagg gcctgtccgc cttctacctc tcctactttg acatgctgta ccctgaggac agcagctggg cagccaaggc ccctggggcc agcagtcggg aggagccacc tgaggagcct gagcagtgcc cggtcattga cagccaagcc ccagcgggca gcctggactt ggtgcccggc gggctgacct tggaggagca ctcgctggag caggtgcagt ccatggtggt gggcgaagtg ctcaaggaca tcgagacggc ctgcaagctg ctcaacatca ccgcagatcc catggactgg agccccagca atgtgcagaa gtggctcctg tggacagagc accaataccg gctgcccccc atgggcaagg ccttccagga gctggcgggc aaggagctgt gcgccatgtc ggaggagcag ttccgccagc gctcgcccct gggtggggat gtgctgcacg cccacctgga catctggaag tcagcggcct ggatgaaaga gcggacttca cctggggcga ttcactactg tgcctcgacc agtgaggaga gctggaccga cagcgaggtg gactcatcat gctccgggca gcccatccac ctgtggcagt tcctcaagga gttgctactc aagccccaca gctatggccg cttcattagg tggctcaaca aggagaaggg catcttcaaa attgaggact cagcccaggt ggcccggctg tggggcatcc gcaagaaccg tcccgccatg aactacgaca agctgagccg ctccatccgc cagtattaca agaagggcat catccggaag ccagacatct cccagcgcct cgtctaccag ttcgtgcacc ccatctga
OMIM
608144
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of SPDEF cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for SPDEF. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,715 Da
NCBI Official Full Name
Homo sapiens SAM pointed domain containing ets transcription factor, mRNA
NCBI Official Synonym Full Names
SAM pointed domain containing ETS transcription factor
NCBI Official Symbol
SPDEF  [Similar Products]
NCBI Official Synonym Symbols
PDEF; bA375E1.3
  [Similar Products]
NCBI Protein Information
SAM pointed domain-containing Ets transcription factor
UniProt Protein Name
SAM pointed domain-containing Ets transcription factor
UniProt Synonym Protein Names
Prostate epithelium-specific Ets transcription factor; Prostate-specific Ets; Prostate-derived Ets factor
UniProt Gene Name
SPDEF  [Similar Products]
UniProt Synonym Gene Names
PDEF; PSE; Prostate-specific Ets  [Similar Products]
UniProt Entry Name
SPDEF_HUMAN
NCBI Summary for SPDEF
The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
UniProt Comments for SPDEF
SPDEF: May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT- 3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter. Belongs to the ETS family.

Protein type: Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: nucleus

Biological Process: cell differentiation; multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter; positive regulation of apoptosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with SPDEF cdna clone
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