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SPP1 protein :: Osteopontin Protein

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Catalog # MBS173394
Unit / Price
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  0.025 mg  /  $395 +1 FREE 8GB USB
  0.1 mg  /  $840 +1 FREE 8GB USB
  1 mg  /  $2,325 +2 FREE 8GB USB
SPP1 protein
Product Name

Osteopontin (SPP1), Protein

Popular Item
Full Product Name

Osteopontin, Human Breast Milk

Product Synonym Names
OPN, Bone sialoprotein, BSP-1
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
166490
Host
Human Milk
Purity/Purification
>= 95% (SDS-PAGE, multiple bands 40-60 kDa, representing variants in glycosylation)
Form/Format
Solution in 10mM Sodium Phosphate, 150mM sodium chloride, and 0.1% sodium azide, pH7.2.
Source
Human Breast Milk
Appearance
Frozen liquid
Protein
1.7mg/ml (E0.1%280nm=0.67)
Preparation and Storage
At -20 degree C
Avoid freeze/thaws
Shipping: Ships with Dry Ice
Other Notes
Small volumes of SPP1 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
SPP1 protein
Custom preparations, technical support, bulk quantities and aliquoting available.

Research has been found that OPN interacts with multiple cell surface receptors which are ubiquitously expressed making it an active player in many physiological and pathological processes including wound healing, bone turnover, tumorigenesis, inflammation, ischemia and immune responses. Therefore studies have shown that manipulation of plasma OPN levels may be useful in the treatment of autoimmune diseases, cancer metastasis, osteoporosis and some forms of stress.

Osteopontin has been implicated in autoimmune diseases such as rheumatoid arthritis, autoimmune hepatitis, and multiple sclerosis. According to current research Osteopontin has also been associated with allergic inflammation and asthma, plays a number of roles in the diseases of skeletal muscles and has been found to be overexpressed in a variety of cancers such as lung cancer, breast cancer, colorectal cancer, stomach cancer and ovarian cancer.
Applications Tested/Suitable for SPP1 protein
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for SPP1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,000 - 60,000 (glycosylation)[Similar Products]
NCBI Official Full Name
osteopontin
NCBI Official Synonym Full Names
secreted phosphoprotein 1
NCBI Official Symbol
NCBI Official Synonym Symbols
OPN; BNSP; BSPI; ETA-1
  [Similar Products]
NCBI Protein Information
osteopontin; uropontin; nephropontin; SPP1/CALPHA1 fusion; urinary stone protein; early T-lymphocyte activation 1; osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein; secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)
UniProt Protein Name
Osteopontin
UniProt Synonym Protein Names
Bone sialoprotein 1; Nephropontin; Secreted phosphoprotein 1; SPP-1; Urinary stone protein; Uropontin
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
BNSP; OPN; SPP-1  [Similar Products]
UniProt Entry Name
OSTP_HUMAN
NCBI Summary for SPP1
The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
UniProt Comments for SPP1
osteopontin: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Belongs to the osteopontin family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q22.1

Cellular Component: extracellular space; cell projection; perinuclear region of cytoplasm; apical part of cell; extracellular region

Molecular Function: protein binding; extracellular matrix binding; cytokine activity

Biological Process: osteoblast differentiation; extracellular matrix disassembly; neutrophil chemotaxis; extracellular matrix organization and biogenesis; response to vitamin D; response to steroid hormone stimulus; biomineral formation; negative regulation of collateral sprouting of intact axon in response to injury; positive regulation of bone resorption; decidualization; inflammatory response; cell adhesion; embryo implantation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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