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Src recombinant protein :: Neuronal proto-oncogene tyrosine-protein kinase Src (Src) Recombinant Protein

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Catalog # MBS957954
Unit / Price
  0.05 mg (E-Coli)  /  $965 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,160 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $1,290 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,395 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,410 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,425 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,470 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,580 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $2,030 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,105 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,125 +2 FREE 8GB USB
  1 mg (Yeast)  /  $2,405 +3 FREE 8GB USB
  1 mg (Baculovirus)  /  $2,765 +3 FREE 8GB USB
Src recombinant protein
Product Name

Neuronal proto-oncogene tyrosine-protein kinase Src (Src), Recombinant Protein

Also Known As

Recombinant Mouse Neuronal proto-oncogene tyrosine-protein kinase Src (Src)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
2-541\naa, Full Length of Mature Protein
Sequence Length
541
Sequence
GSNKSKPKDA SQRRRSLEPS ENVHGAGGAF PASQTPSKPA SADGHRGPSA AFVPPAAEPK LFGGFNSSDT VTSPQRAGPL AGGVTTFVAL YDYESRTETD LSFKKGERLQ IVNNTRKVDV REGDWWLAHS LSTGQTGYIP SNYVAPSDSI QAEEWYFGKI TRRESERLLL NAENPRGTFL VRESETTKGA YCLSVSDFDN AKGLNVKHYK IRKLDSGGFY ITSRTQFNSL QQLVAYYSKH ADGLCHRLTT VCPTSKPQTQ GLAKDAWEIP RESLRLEVKL GQGCFGEVWM GTWNGTTRVA IKTLKPGTMS PEAFLQEAQV MKKLRHEKLV QLYAVVSEEP IYIVTEYMNK GSLLDFLKGE TGKYLRLPQL VDMSAQIASG MAYVERMNYV HRDLRAANIL VGENLVCKVA DFGLARLIED NEYTARQGAK FPIKWTAPEA ALYGRFTIKS DVWSFGILLT ELTTKGRVPY PGMVNREVLD QVERGYRMPC PPECPESLHD LMCQCWRKEP EERPTFEYLQ AFLEDYFTST EPQYQPGENL
3D Structure
ModBase 3D Structure for P05480
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Mouse
Storage Buffer
Tris-based buffer, 50% glycerol
Tag Information
Tag type will be determined during the manufacturing process
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of Src recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Src recombinant protein
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. This protein is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
NCBI/Uniprot data below describe general gene information for Src. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
60,645 Da
NCBI Official Full Name
neuronal proto-oncogene tyrosine-protein kinase Src isoform 2
NCBI Official Synonym Full Names
Rous sarcoma oncogene
NCBI Official Symbol
NCBI Official Synonym Symbols
AW259666; pp60c-src
  [Similar Products]
NCBI Protein Information
neuronal proto-oncogene tyrosine-protein kinase Src
UniProt Protein Name
Neuronal proto-oncogene tyrosine-protein kinase Src
UniProt Synonym Protein Names
Proto-oncogene c-Src; pp60c-src; p60-Src
UniProt Gene Name
UniProt Synonym Gene Names
p60-Src  [Similar Products]
UniProt Comments for Src
Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (PubMed:9344858). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1. Plays a role in EGF-mediated calcium-activated chloride channel activation (). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-738'. Enhances DDX58/RIG-I-elicited antiviral signaling. Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376'. Phosphorylates BCAR1 at 'Tyr-226'. Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity. Involved in anchorage-independent cell growth (). Required for podosome formation (PubMed:21525037).
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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