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Srd5a1 recombinant protein :: 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Srd5a1) Recombinant Protein

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Catalog # MBS966376
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Srd5a1 recombinant protein
Product Name

3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Srd5a1), Recombinant Protein

Also Known As

Recombinant Rat 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Srd5a1)

Product Synonym Names
Recombinant 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Srd5a1); 3-oxo-5-alpha-steroid 4-dehydrogenase 1 EC= 1.3.99.5; SR type 1 Steroid 5-alpha-reductase 1; S5AR 1
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-259
Sequence Length
259
Sequence
MVPLMELDEL CLLDMLVYLE GFMAFVSIVG LRSVGSPYGR YSPQWPGIRV PARPAWFIQE LPSMAWPLYE YIRPAAARLG NLPNRVLLAM FLIHYVQRTL VFPVLIRGGK PTLLVTFVLA FLFCTFNGYV QSRYLSQFAV YAEDWVTHPC FLTGFALWLV GMVINIHSDH ILRNLRKPGE TGYKIPRGGL FEYVSAANYF GELVEWCGFA LASWSLQGVV FALFTLSTLL TRAKQHHQWY HEKFEDYPKS RKILIPFVL
Chromosome Location
Chromosome: 1; NC_005100.3 (37717526..37751716). Location: 17p14
3D Structure
ModBase 3D Structure for P24008
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Rattus norvegicus (Rat)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of Srd5a1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Srd5a1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,780 Da[Similar Products]
NCBI Official Full Name
3-oxo-5-alpha-steroid 4-dehydrogenase 1
NCBI Official Synonym Full Names
steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
NCBI Official Symbol
Srd5a1  [Similar Products]
NCBI Official Synonym Symbols
S5AR 1
  [Similar Products]
NCBI Protein Information
3-oxo-5-alpha-steroid 4-dehydrogenase 1; SR type 1; steroid 5 alpha-reductase 1; steroid 5-alpha-reductase 1; steroid-5-alpha-reductase 1
UniProt Protein Name
3-oxo-5-alpha-steroid 4-dehydrogenase 1
UniProt Synonym Protein Names
SR type 1; Steroid 5-alpha-reductase 1
UniProt Gene Name
Srd5a1  [Similar Products]
UniProt Synonym Gene Names
S5AR 1  [Similar Products]
UniProt Entry Name
S5A1_RAT
NCBI Summary for Srd5a1
catalyzes the conversion of testosterone to dihydrotestosterone; required for male sex differentiation [RGD, Feb 2006]
UniProt Comments for Srd5a1
Function: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.

Catalytic activity: 5-alpha-pregnan-3,20-dione + NADP+ = progesterone + NADPH.

Subcellular location: Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein

Potential.

Tissue specificity: Liver and prostate (at a low level).

Developmental stage: After the establishment of chromosomal sex at fertilization.

Induction: Its expression is regulated by androgens such as testosterone.

Sequence similarities: Belongs to the steroid 5-alpha reductase family.

Biophysicochemical propertiespH dependence:Optimally active at alkaline pHs.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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