NP_001005291.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
121,675 Da
NCBI Official Full Name
sterol regulatory element-binding protein 1 isoform a
NCBI Official Synonym Full Names
sterol regulatory element binding transcription factor 1
NCBI Protein Information
sterol regulatory element-binding protein 1; SREBP-1; class D basic helix-loop-helix protein 1
UniProt Protein Name
Sterol regulatory element-binding protein 1
UniProt Synonym Protein Names
Class D basic helix-loop-helix protein 1; bHLHd1; Sterol regulatory element-binding transcription factor 1Cleaved into the following chain:Processed sterol regulatory element-binding protein 1
UniProt Synonym Gene Names
UniProt Entry Name
SRBP1_HUMAN
NCBI Summary for SREBF1
This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for SREBF1
SREBP-1: Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle. Belongs to the SREBP family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component: Golgi membrane; nucleoplasm; endoplasmic reticulum membrane; protein complex; endoplasmic reticulum; cytoplasm; integral to membrane; nuclear envelope; nucleus; cytosol
Molecular Function: protein dimerization activity; protein binding; sterol response element binding; DNA binding; sequence-specific DNA binding; protein complex binding; chromatin binding; transcription factor activity; protein kinase binding
Biological Process: circadian rhythm; response to cAMP; response to glucagon stimulus; lipid biosynthetic process; positive regulation of cholesterol biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; cellular lipid metabolic process; negative regulation of insulin secretion; positive regulation of histone deacetylation; regulation of fatty acid metabolic process; response to glucose stimulus; aging; response to drug; response to food; cholesterol metabolic process; response to retinoic acid; transcription, DNA-dependent; cellular response to starvation; regulation of transcription from RNA polymerase II promoter; chemical signal regulation of heart rate; insulin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; lipid metabolic process; response to progesterone stimulus; lung development
Research Articles on SREBF1
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Pathways associated with SREBF1 elisa kit
Diseases associated with SREBF1 elisa kit
Organs/Tissues associated with SREBF1 elisa kit
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