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anti-SREBP-1 antibody :: anti-Human, Rat SREBP-1 Antibody

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Catalog # MBS854001
Unit / Price
  0.1 mg  /  $215 +1 FREE 8GB USB
Western Blot (WB)
Product Name

SREBP-1, Antibody

Full Product Name

SREBP-1 (Ab-439) Antibody

Product Synonym Names
SRBP1; SREBF1; SREBP1; sterol regulatory element-binding protein 1; sterol regulatory element-binding transcription factor 1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P36956
Species Reactivity
Human, Rat
SREBP-1 (Ab-439) antibody detects endogenous levels of total SREBP-1 protein.
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
The antiserum was produced against synthesized non-phosphopeptide derived from human SREBP-1 around the phosphorylation site of serine 439 (Q-S-SP-P-L).
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-SREBP-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-SREBP-1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-SREBP-1 antibody
WB: 1:500~1:1000
ELISA: 1:20000

Western Blot (WB) of anti-SREBP-1 antibody
Western blot analysis of extracts from Jurkat cells, treated with TNF (200ng/ml, 30mins), using SREBP-1 (Ab-439) antibody.
anti-SREBP-1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for SREBP-1. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,816 Da
NCBI Official Full Name
sterol regulatory element-binding protein 1 isoform a
NCBI Official Synonym Full Names
sterol regulatory element binding transcription factor 1
NCBI Official Symbol
SREBF1  [Similar Products]
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
sterol regulatory element-binding protein 1
UniProt Protein Name
Sterol regulatory element-binding protein 1
UniProt Synonym Protein Names
Class D basic helix-loop-helix protein 1; bHLHd1
UniProt Gene Name
SREBF1  [Similar Products]
UniProt Synonym Gene Names
BHLHD1; SREBP1; SREBP-1; bHLHd1  [Similar Products]
NCBI Summary for SREBP-1
This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively. [provided by RefSeq, Nov 2017]
UniProt Comments for SREBP-1
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').
Product References and Citations for anti-SREBP-1 antibody
Yokoyama C., Cell 75:187-197(1993). Hua X., Genomics 25:667-673(1995). Olsen J.V., Cell 127:635-648(2006).

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