NP_002718.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,652 Da
NCBI Official Full Name
serglycin
NCBI Official Synonym Full Names
serglycin
NCBI Protein Information
serglycin; p.PG; serglycin proteoglycan; proteoglycan 1, secretory granule; platelet proteoglycan core protein; hematopoetic proteoglycan core peptide; hematopoetic proteoglycan core protein; hematopoietic proteoglycan core protein; secretory granule proteoglycan core peptide; secretory granule proteoglycan core protein; proteoglycan protein core for mast cell secretory granule
UniProt Protein Name
Serglycin
UniProt Synonym Protein Names
Hematopoietic proteoglycan core protein; Platelet proteoglycan core protein; P.PG; Secretory granule proteoglycan core protein
UniProt Synonym Gene Names
UniProt Entry Name
SRGN_HUMAN
NCBI Summary for SRGN
This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene. [provided by RefSeq, Jul 2010]
UniProt Comments for SRGN
SRGN: Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF- alpha and may also regulate protease secretion. Inhibits bone mineralization. Belongs to the serglycin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 10q22.1
Cellular Component: Golgi membrane; Golgi apparatus; extracellular space; mast cell granule; extracellular region
Molecular Function: collagen binding; protein binding
Biological Process: maintenance of granzyme B localization in T cell secretory granule; negative regulation of bone mineralization; platelet activation; platelet degranulation; induction of apoptosis by granzyme; biomineral formation; negative regulation of cytokine secretion; T cell secretory granule organization and biogenesis; protein processing; maintenance of protease localization in mast cell secretory granule; mast cell secretory granule organization and biogenesis; blood coagulation
Research Articles on SRGN
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Products associated with SRGN elisa kit
Pathways associated with SRGN elisa kit
Diseases associated with SRGN elisa kit
Organs/Tissues associated with SRGN elisa kit
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