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SSB La native protein

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Catalog # MBS537359
Unit / Price
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  0.2 mg  /  $560 +1 FREE 8GB USB
SSB La native protein
Product Name

SSB La, Native Protein

Popular Item
Full Product Name

SSB La protein

Product Synonym Names
SSB protein; Single stranded binding protein; Single stranded binding La protein
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
109090
Host
Bovine
Purity/Purification
> 90% pure
Form/Format
20mM Hepes-NaOH, pH 7.4, with 0.32M NaCl, 0.2mM dithiothreitol, 0.1mM PMSF, 20% glycerol, and stabilizers.
Source Note
Calf Thymus
Protein Type
Native
Biological Significance
La antigen binds to the oligo(U) 3' termini of nascent RNA polymerase III transcripts and facilitates transcriptional termination and reinitiation by this enzyme13,-17. It has also been reported to function as an ATP-dependent helicase able to melt RNA-DNA hybrids.
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of SSB La native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
SSB La native protein
Purified native Bovine SSB La protein
Product Categories/Family for SSB La native protein
Applications Tested/Suitable for SSB La native protein
ELISA (EIA)
Application Notes for SSB La native protein
0.5-1 ug/ml
NCBI/Uniprot data below describe general gene information for SSB La. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48 kDa
NCBI Official Full Name
Sjogren syndrome antigen B (autoantigen La)
NCBI Official Synonym Full Names
Sjogren syndrome antigen B (autoantigen La)
NCBI Official Symbol
NCBI Official Synonym Symbols
La; LARP3; La/SSB
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NCBI Protein Information
lupus La protein
UniProt Protein Name
Lupus La protein
UniProt Synonym Protein Names
La autoantigen; La ribonucleoprotein; Sjoegren syndrome type B antigen; SS-B
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
LA_HUMAN
NCBI Summary for SSB La
The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]
UniProt Comments for SSB La
SSB: a nuclear protein that plays a role in the transcription of RNA polymerase III. It is most probably a transcription termination factor. Binds to the 3' termini of virtually all nascent polymerase III transcripts. It is associated with precursor forms of RNA polymerase III transcripts including tRNA and 4.5S, 5s, 7s, and 7-2 RNAs.

Protein type: Transcription initiation complex

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: nucleus; ribonucleoprotein complex

Molecular Function: mRNA binding; protein binding; nucleotide binding; tRNA binding

Biological Process: RNA processing; histone mRNA metabolic process; tRNA modification
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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