NP_001039.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
12,736 Da
NCBI Official Full Name
somatostatin preproprotein
NCBI Official Synonym Full Names
somatostatin
NCBI Official Synonym Symbols
NCBI Protein Information
somatostatin; growth hormone release-inhibiting factor; prepro-somatostatin; somatostatin-14; somatostatin-28
UniProt Protein Name
Somatostatin
UniProt Synonym Protein Names
Growth hormone release-inhibiting factorCleaved into the following 2 chains:Somatostatin-28; Somatostatin-14
UniProt Entry Name
SMS_HUMAN
NCBI Summary for SST
The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008]
UniProt Comments for SST
SST: Somatostatin inhibits the release of somatotropin. Belongs to the somatostatin family.
Protein type: Secreted, signal peptide; Secreted; Hormone
Chromosomal Location of Human Ortholog: 3q28
Cellular Component: extracellular space; cell soma; extracellular region
Molecular Function: hormone activity
Biological Process: response to drug; induction of apoptosis by hormones; response to amino acid stimulus; regulation of cell migration; G-protein coupled receptor protein signaling pathway; negative regulation of cell proliferation; synaptic transmission; hyperosmotic response; cell surface receptor linked signal transduction; cell-cell signaling; response to heat; response to steroid hormone stimulus; digestion; response to nutrient
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Products associated with SST native protein
Pathways associated with SST native protein
Diseases associated with SST native protein
Organs/Tissues associated with SST native protein
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