AAA19452.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
87,967 Da
NCBI Official Full Name
Stat3
NCBI Official Synonym Full Names
signal transducer and activator of transcription 3
NCBI Protein Information
signal transducer and activator of transcription 3; acute phase response factor; acute-phase response factor
UniProt Protein Name
Signal transducer and activator of transcription 3
UniProt Synonym Protein Names
Acute-phase response factor
UniProt Synonym Gene Names
UniProt Entry Name
STAT3_MOUSE
UniProt Comments for STAT3
STAT3: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Constitutively active in a number of human tumors. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described.
Protein type: DNA-binding; Nuclear receptor co-regulator; Motility/polarity/chemotaxis; Transcription factor
Cellular Component: nucleoplasm; mitochondrion; mitochondrial inner membrane; cytoplasm; plasma membrane; intracellular; nucleus
Molecular Function: protein dimerization activity; signal transducer activity; protein binding; ligand-dependent nuclear receptor activity; DNA binding; sequence-specific DNA binding; transcription factor binding; protein phosphatase binding; transcription factor activity; protein kinase binding; glucocorticoid receptor binding; CCR5 chemokine receptor binding
Biological Process: transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; radial glial cell differentiation; thermoregulation; glucose homeostasis; signal transduction; response to estradiol stimulus; negative regulation of cell proliferation; astrocyte differentiation; regulation of transcription, DNA-dependent; protein import into nucleus; acute-phase response; negative regulation of glycolysis; positive regulation of Notch signaling pathway; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; eating behavior; cytokine and chemokine mediated signaling pathway; stem cell maintenance; regulation of multicellular organism growth; JAK-STAT cascade; cellular response to hormone stimulus; cell proliferation; sexual reproduction; response to cytokine stimulus; positive regulation of transcription from RNA polymerase II promoter; regulation of mitochondrial membrane permeability; eye photoreceptor cell differentiation; phosphorylation
Research Articles on STAT3
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Pathways associated with STAT3 elisa kit
Diseases associated with STAT3 elisa kit
Organs/Tissues associated with STAT3 elisa kit
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