• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-SYN antibody :: alpha-Synuclein Antibody

Scan QR to view Datasheet
Catalog # MBS857701
Unit / Price
Scan QR to view Datasheet
  0.1 mg  /  $215 +1 FREE 8GB USB
  0.05 mg  /  $225 +1 FREE 8GB USB
Western Blot (WB)
Product Name

alpha-Synuclein, Antibody

Popular Item
Full Product Name

alpha-Synuclein (Phospho-Ser129) Antibody

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
127750
3D Structure
ModBase 3D Structure for P37840
Species Reactivity
Human, Mouse, Rat
Specificity
alpha-Synuclein (phospho-Ser129) antibody detects endogenous levels ofalpha-Synuclein only when phosphorylated at serine 129.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized phosphopeptide derived from humanalpha-Synuclein around the phosphorylation site of serine 129 (M-P-SP-E-E).
Preparation and Storage
Store at-20 degree C for 1 year
Other Notes
Small volumes of anti-SYN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-SYN antibody
Western Blot (WB)
Application Notes for anti-SYN antibody
WB: 1:500-1000

Western Blot (WB) of anti-SYN antibody
Western blot analysis of extract from mouse brain tissue, usingalpha-Synuclein (phospho-Ser129) antibody.
anti-SYN antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for SYN. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
13,109 Da
NCBI Official Full Name
alpha-synuclein isoform NACP140
NCBI Official Synonym Full Names
synuclein alpha
NCBI Official Symbol
NCBI Official Synonym Symbols
PD1; NACP; PARK1; PARK4
  [Similar Products]
NCBI Protein Information
alpha-synuclein
UniProt Protein Name
Alpha-synuclein
UniProt Synonym Protein Names
Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
NACP; PARK1; NACP  [Similar Products]
NCBI Summary for SYN
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
UniProt Comments for SYN
May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
Product References and Citations for anti-SYN antibody
Jakowec MW, et al.(2001)Dev Neurosci.23(2):91-9. Kitamura Y, et al.(2001)Brain Res.898(1):181-5. El-Agnaf OM, et al.(2006)FASEB J.20(3):419-25.

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000