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TARDBP cdna clone

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Catalog # MBS1276476
Unit / Price
  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
TARDBP cdna clone
Product Name

TARDBP, cDNA Clone

Popular Item
Also Known As

TARDBP cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
783
Sequence
atgtctgaat atattcgggt aaccgaagat gagaacgatg agcccattga aataccatcg gaagacgatg ggacggtgct gctctccacg gttacagccc agtttccagg ggcgtgtggg cttcgctaca ggaatccagt gtctcagtgt atgagaggtg tccggctggt agaaggaatt ctgcatgccc cagatgctgg ctggggaaat ctggtgtatg ttgtcaacta tccaaaagat aacaaaagaa aaatggatga gacagatgct tcatcagcag tgaaagtgaa aagagcagtc cagaaaacat ccgatttaat agtgttgggt ctcccatgga aaacaaccga acaggacctg aaagagtatt ttagtacctt tggagaagtt cttatggtgc aggtcaagaa agatcttaag actggtcatt caaaggggtt tggctttgtt cgttttacgg aatatgaaac acaagtgaaa gtaatgtcac agcgacatat gatagatgga cgatggtgtg actgcaaact tcctaattct aagcaaagcc aagatgagcc tttgagaagc agaaaagtgt ttgtggggcg ctgtacagag gacatgactg aggatgagct gcgggagttc ttctctcagt acggggatgt gatggatgtc ttcatcccca agccattcag ggcctttgcc tttgttacat ttgcagatga tcagattgcg cagtctcttt gtggagagga cttgatcatt aaaggaatca gcgttcatat atccaatgcc taa
OMIM
605078
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of TARDBP cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for TARDBP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
31,808 Da
NCBI Official Full Name
Homo sapiens TAR DNA binding protein, mRNA
NCBI Official Synonym Full Names
TAR DNA binding protein
NCBI Official Symbol
TARDBP  [Similar Products]
NCBI Official Synonym Symbols
ALS10; TDP-43
  [Similar Products]
NCBI Protein Information
TAR DNA-binding protein 43
UniProt Protein Name
TAR DNA-binding protein 43
Protein Family
UniProt Gene Name
TARDBP  [Similar Products]
UniProt Synonym Gene Names
TDP43; TDP-43  [Similar Products]
UniProt Entry Name
TADBP_HUMAN
NCBI Summary for TARDBP
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]
UniProt Comments for TARDBP
TARDBP: DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR. Homodimer. Binds specifically to pyrimidine-rich motifs of TAR DNA and to single stranded TG repeated sequences. Binds to RNA, specifically to UG repeated sequences with a minimun of six contiguous repeats. Interacts with ATNX2; the interaction is RNA-dependent. Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 1p36.22

Cellular Component: nucleoplasm; nucleus

Molecular Function: double-stranded DNA binding; identical protein binding; mRNA 3'-UTR binding; protein binding; RNA binding; transcription factor activity

Biological Process: negative regulation of protein amino acid phosphorylation; nuclear fragmentation during apoptosis; regulation of cell cycle; RNA splicing

Disease: Amyotrophic Lateral Sclerosis 10, With Or Without Frontotemporal Dementia
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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