BC130439
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,841 Da
NCBI Official Full Name
Homo sapiens taste receptor, type 2, member 4, mRNA
NCBI Official Synonym Full Names
taste 2 receptor member 4
NCBI Official Synonym Symbols
NCBI Protein Information
taste receptor type 2 member 4
UniProt Protein Name
Taste receptor type 2 member 4
UniProt Synonym Gene Names
UniProt Entry Name
TA2R4_HUMAN
NCBI Summary for TAS2R4
This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]
UniProt Comments for TAS2R4
TAS2R4: Gustducin-coupled receptor for denatonium and N(6)- propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. Belongs to the G-protein coupled receptor T2R family.
Protein type: Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, T2R family
Chromosomal Location of Human Ortholog: 7q31.3-q32
Cellular Component: integral to membrane; plasma membrane
Molecular Function: bitter taste receptor activity; taste receptor activity
Biological Process: detection of chemical stimulus involved in sensory perception of bitter taste; sensory perception of taste; signal transduction
Research Articles on TAS2R4
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Pathways associated with TAS2R4 cdna clone
Diseases associated with TAS2R4 cdna clone
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