NP_001116538.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
80,941 Da
NCBI Official Full Name
microtubule-associated protein tau isoform 6
NCBI Official Synonym Full Names
microtubule associated protein tau
NCBI Official Synonym Symbols
TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103 [Similar Products]
NCBI Protein Information
microtubule-associated protein tau
UniProt Protein Name
Microtubule-associated protein tau
UniProt Synonym Protein Names
Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau
UniProt Synonym Gene Names
NCBI Summary for Tau
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
UniProt Comments for Tau
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Product References and Citations for anti-Tau antibody
Goedert M., Proc. Natl. Acad. Sci. U.S.A. 85:4051-4055(1988). Goedert M., EMBO J. 8:393-399(1989). Lee G., Neuron 2:1615-1624(1989).
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Products associated with anti-Tau antibody
Pathways associated with anti-Tau antibody
Diseases associated with anti-Tau antibody
Organs/Tissues associated with anti-Tau antibody
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