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TAU recombinant protein :: Microtubule-associated protein tau Recombinant Protein

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Catalog # MBS9422386
Unit / Price
  0.01 mg  /  $230 +1 FREE 8GB USB
  0.05 mg  /  $290 +1 FREE 8GB USB
  0.1 mg  /  $455 +1 FREE 8GB USB
  0.2 mg  /  $705 +1 FREE 8GB USB
  0.5 mg  /  $1,145 +1 FREE 8GB USB
  1 mg  /  $1,800 +2 FREE 8GB USB
TAU recombinant protein
Product Name

Microtubule-associated protein tau, Recombinant Protein

Popular Item
Also Known As

Recombinant Rat Microtubule-associated protein tau

Product Synonym Names
Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
Full Length, 2-752aa
Sequence
AEPRQEFDTM EDQAGDYTML QDQEGDMDHG LKESPPQPPA DDGSEEPGSE TSDAKSTPTA EDVTAPLVEE RAPDKQATAQ SHTEIPEGTT AEEAGIGDTP NMEDQAAGHV TQEPQKVEIF SQSLLVEPGR REGQAPDSGI SDWTHQQVPS MSGAPLPPQG LREATHQPLG TRPEDVERSH PASELLWQES PQKEAWGKDR LGSEEEVDED ITMDESSQES PPSQASLAPG TATPQARSVS ASGVSGETTS IPGFPAEGSI PLPADFFSKV SAETQASPPE GPGTGPSEEG HEAAPEFTFH VEIKASAPKE QDLEGATVVG APAEEQKARG PSVGKGTKEA SLLEPTDKQP AAGLPGRPVS RVPQLKARVA GVSKDRTGND EKKAKTSTPS CAKTPSNRPC LSPTRPTPGS SDPLIKPSSP AVCPEPATSP KYVSSVTPRN GSPGTKQMKL KGADGKTGAK IATPRGAATP GQKGTSNATR IPAKTTPSPK TPPGSGEPPK SGERSGYSSP GSPGTPGSRS RTPSLPTPPT REPKKVAVVR TPPKSPSASK SRLQTAPVPM PDLKNVRSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHV PGGGSVHIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS GDTSPRHLSN VSSTGSIDMV DSPQLATLAD EVSASLAKQG L
3D Structure
ModBase 3D Structure for P19332
Host
Yeast
Species Reactivity
Rat
Purity/Purification
Greater than 90% as determined by SDS-PAGE.
Form/Format
20mM Tris-HCl based buffer, pH8.0
Tag Info
His-tag
Preparation and Storage
Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Other Notes
Small volumes of TAU recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
TAU recombinant protein
Promotes microtubule assbly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma mbrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
NCBI/Uniprot data below describe general gene information for TAU. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
80.4kD
NCBI Official Full Name
Microtubule-associated protein tau
NCBI Official Synonym Full Names
microtubule-associated protein tau
NCBI Official Symbol
NCBI Official Synonym Symbols
Tau; pTau; Mtapt; RNPTAU
  [Similar Products]
NCBI Protein Information
microtubule-associated protein tau
UniProt Protein Name
Microtubule-associated protein tau
UniProt Synonym Protein Names
Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau
UniProt Gene Name
UniProt Synonym Gene Names
Mtapt; Tau; PHF-tau  [Similar Products]
NCBI Summary for TAU
a microtubule-associated protein; expression is found specifically in neurons [RGD, Feb 2006]
UniProt Comments for TAU
Tau: a microtubule-associated protein that regulates microtubule assembly and stability. Apparently involved in the establishment and maintenance of neuronal polarity. Mutations can result in several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. Nine differentially spliced isoforms have been described. The short isoforms allow plasticity of the cytoskeleton, whereas the longer isoforms may preferentially play a role in its stabilization.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 10q32.1

Cellular Component: axolemma; axon; axoneme; cell soma; cytoplasm; cytosol; dendrite; growth cone; internal side of plasma membrane; membrane; microtubule; microtubule associated complex; microtubule cytoskeleton; neuron projection; nuclear speck; nucleus; plasma membrane; postsynaptic density; tubulin complex

Molecular Function: apolipoprotein binding; DNA binding; enzyme binding; Hsp90 protein binding; identical protein binding; microtubule binding; protein binding; protein complex binding; protein domain specific binding; protein homodimerization activity; protein kinase binding; protein phosphatase 2A binding; receptor agonist activity; SH3 domain binding

Biological Process: adult walking behavior; apoptosis; axon cargo transport; axon extension; axonogenesis; brain development; female pregnancy; induction of apoptosis by oxidative stress; intracellular distribution of mitochondria; memory; microtubule cytoskeleton organization and biogenesis; mitochondrion transport along microtubule; negative regulation of intracellular transport; negative regulation of kinase activity; neurite development; neuron migration; positive regulation of axon extension; positive regulation of microtubule polymerization; positive regulation of superoxide release; regulation of autophagy; regulation of calcium-mediated signaling; regulation of microtubule polymerization or depolymerization; response to nutrient; response to organic substance; synapse organization and biogenesis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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