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tax recombinant protein :: T-cell leukemia virus 1 Protein Tax-1 (Tax) Recombinant Protein

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Catalog # MBS1104033
Unit / Price
Scan QR to view Datasheet
  0.05 mg (E-Coli)  /  $765 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $860 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $1,020 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,090 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,125 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,160 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,315 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,330 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,575 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,700 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,050 +2 FREE 8GB USB
  1 mg (Yeast)  /  $2,090 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,160 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $3,170 +3 FREE 8GB USB
tax recombinant protein
Product Name

T-cell leukemia virus 1 Protein Tax-1 (Tax), Recombinant Protein

Popular Item
Full Product Name

Recombinant Human T-cell leukemia virus 1 Protein Tax-1 (Tax)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS1104033 COA
Sequence Positions
1-353. Full length
Sequence
MAHFPGFGQS LLFGYPVYVF GDCVQGDWCP ISGGLCSARL HRHALLATCP EHQITWDPID GRVIGSALQF LIPRLPSFPT QRTSKTLKVL TPPITHTTPN IPPSFLQAMR KYSPFRNGYM EPTLGQHLPT LSFPDPGLRP QNLYTLWGGS VVCMYLYQLS PPITWPLLPH VIFCHPGQLG AFLTNVPYKR IEELLYKISL TTGALIILPE DCLPTTLFQP ARAPVTLTAW QNGLLPFHST LTTPGLIWTF TDGTPMISGP CPKDGQPSLV LQSSSFIFHK FQTKAYHPSF LLSHGLIQYS SFHSLHLLFE EYTNIPISLL FNEKEADDND HEPQISPGGL EPPSEKHFRE TEV
3D Structure
ModBase 3D Structure for P03409
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1)
Storage Buffer
Tris-based buffer, 50% glycerol
Tag Information
Tag type will be determined during the manufacturing process
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of tax recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for tax. It may not necessarily be applicable to this product.
NCBI GI #
NCBI Accession #
UniProt Primary Accession #
Molecular Weight
39,471 Da
NCBI Official Full Name
Protein Tax-1
UniProt Protein Name
Protein Tax-1
UniProt Synonym Protein Names
Protein X-LOR; Protein PX; Trans-activating transcriptional regulatory protein of HTLV-1
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
Protein PX  [Similar Products]
UniProt Comments for tax
Transcriptional activator that activates both the viral long terminal repeat (LTR) and cellular promoters via activation of CREB, NF-kappa-B, SRF and AP-1 pathways. Binds to three 21 bp repeat elements located within the LTRs, referred to as Tax-responsive elements (TRE). Binding to TRE requires the interaction with CREB1 and CREBBP. Also induces chromatin remodeling of proviral LTR-mediated gene expression by recruiting the histone acetyl transferases CREBBP and EP300 to the chromatin, which results in histone acetylation. Via its interaction with IKK regulatory subunit IKBKG, Tax-1 persistently stimulates I-kappa-B kinase (IKK), resulting in constitutive activation of the transcription factor NF-kappa-B. Induction of the nuclear expression of members of the NFkB family of transcription factors, which leads to up-regulated expression of many gene promoters containing NFkB motifs. These genes include those encoding IL2, IL15, IL2RA and IL15RA, leading to autocrine IL2/IL2RA and IL15/IL15RA loops. The resulting T-cell proliferation leads to malignant transformation and to the development of adult T-cell leukemia (ATL). IL13, known to be linked to leukemogenesis, is also up-regulated by Tax-1. Interaction with PDZ domain-containing proteins induce IL2-independent growth, which may be a factor in multi-step leukemogenesis. Inhibits the action of at least three cellular tumor suppressors p53/TP53, RB1 and DLG1, and suppresses their abilities to dictate apoptosis in primary cells. Required for viral replication.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withtax recombinant protein
 Reference Product  PubMed Publications
 FLNA recombinant protein  >12 publications with tax and FLNA
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