BC014983
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48,382 Da
NCBI Official Full Name
Homo sapiens TBC1 domain family, member 20, mRNA
NCBI Official Synonym Full Names
TBC1 domain family member 20
NCBI Protein Information
TBC1 domain family member 20
UniProt Protein Name
TBC1 domain family member 20
UniProt Synonym Gene Names
UniProt Entry Name
TBC20_HUMAN
NCBI Summary for TBC1D20
This gene encodes a protein that belongs to a family of GTPase activator proteins of Rab-like small GTPases. The encoded protein and its cognate GTPase, Rab1, bind the nonstructural protein 5A (NS5A) of the hepatitis C virus (HCV) to mediate viral replication. Depletion of this protein inhibits replication of the virus and HCV infection. Mutations in this gene are associated with Warburg micro syndrome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
UniProt Comments for TBC1D20
TBC1D20: May act as a GTPase-activating protein for Rab family protein(s). 3 isoforms of the human protein are produced by alternative splicing.
Protein type: GAPs; Membrane protein, multi-pass; Membrane protein, integral; GAPs, Rab
Chromosomal Location of Human Ortholog: 20p13
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; integral to Golgi membrane; nuclear membrane
Molecular Function: GTPase activator activity; protein binding; Rab GTPase binding
Biological Process: COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; Golgi organization and biogenesis; positive regulation of GTPase activity; positive regulation of viral protein levels in host cell; virus assembly
Disease: Warburg Micro Syndrome 4
Research Articles on TBC1D20
Precautions
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Diseases associated with TBC1D20 cdna clone
Organs/Tissues associated with TBC1D20 cdna clone
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