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TBC1D8 sirna

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Catalog # MBS8236015
Unit / Price
  15 nmol  /  $365 +1 FREE 8GB USB
  30 nmol  /  $515 +1 FREE 8GB USB
TBC1D8 sirna
Product Name

TBC1D8, siRNA

Also Known As

TBC1D8 siRNA (Human)

Product Synonym Names
VRP; TBC1 domain family member 8; AD 3; Vascular Rab-GAP/TBC-containing protein
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
897
3D Structure
ModBase 3D Structure for O95759
Host
Synthetic
Species Reactivity
Human
Specificity
TBC1D8 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
Purity/Purification
> 97%
Form/Format
Lyophilized powder
Quality Control
Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
Directions for Use
We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
Components
We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human TBC1D8 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Negative Control
siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
Other Notes
Small volumes of TBC1D8 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
TBC1D8 sirna
siRNA to inhibit TBC1D8 expression using RNA interference
Applications Tested/Suitable for TBC1D8 sirna
RNA Interference (RNAi)
NCBI/Uniprot data below describe general gene information for TBC1D8. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
102,741 Da
NCBI Official Full Name
TBC1 domain family member 8
NCBI Official Synonym Full Names
TBC1 domain family, member 8 (with GRAM domain)
NCBI Official Symbol
TBC1D8  [Similar Products]
NCBI Official Synonym Symbols
AD3; VRP; HBLP1; TBC1D8A
  [Similar Products]
NCBI Protein Information
TBC1 domain family member 8
UniProt Protein Name
TBC1 domain family member 8
UniProt Synonym Protein Names
AD 3; Vascular Rab-GAP/TBC-containing protein
Protein Family
UniProt Gene Name
TBC1D8  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
TBCD8_HUMAN
UniProt Comments for TBC1D8
TBC1D8: a putative GTPase activating protein for Rab family protein(s).

Protein type: GAPs; GAPs, Rab

Chromosomal Location of Human Ortholog: 2q11.2

Cellular Component: membrane

Biological Process: blood circulation; positive regulation of cell proliferation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with TBC1D8 sirna
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
Diseases associated with TBC1D8 sirna
Organs/Tissues associated with TBC1D8 sirna
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1 publications with TBC1D8 and Bone
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