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TCF3 peptide :: TCF3 / ITF1 Peptide

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Catalog # MBS425501
Unit / Price
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  0.1 mg  /  $190 +1 FREE 8GB USB
TCF3 peptide
Product Name

TCF3 / ITF1, Peptide

Full Product Name

TCF3 / ITF1 Immunizing Peptide

Product Synonym Names
TCF3; ITF1; transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47); E2A; MGC129647; MGC129648; E2A immunoglobulin enhancer-binding factor E12/E47; immunoglobulin transcription factor 1; kappa-E2-binding factor; transcription factor; TCF3 / ITF1
Product Gene Name
Product Synonym Gene Name
Antibody/Peptide Pairs
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
100ug of dried peptide
Preparation and Storage
Shipped at ambient temperature, store at -20 degree C
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of TCF3 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for TCF3. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
68,510 Da
NCBI Official Full Name
transcription factor E2-alpha isoform E12
NCBI Official Synonym Full Names
transcription factor 3
NCBI Official Symbol
NCBI Official Synonym Symbols
E2A; E47; AGM8; ITF1; VDIR; TCF-3; bHLHb21
  [Similar Products]
NCBI Protein Information
transcription factor E2-alpha
UniProt Protein Name
Transcription factor E2-alpha
UniProt Synonym Protein Names
Class B basic helix-loop-helix protein 21; bHLHb21; Immunoglobulin enhancer-binding factor E12/E47; Immunoglobulin transcription factor 1; Kappa-E2-binding factor; Transcription factor 3; TCF-3; Transcription factor ITF-1
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
BHLHB21; E2A; ITF1; bHLHb21; TCF-3  [Similar Products]
UniProt Entry Name
NCBI Summary for TCF3
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]
UniProt Comments for TCF3
E2A: a transcription factor that plays major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Heterodimers between E2A and tissue-specific basic helix-loop-helix (bHLH) Dimers bind DNA on E-box motifs: 5'- CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Deletions in E2A have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Two alternatively spliced human isoforms have been described.

Protein type: DNA-binding; Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: cytoplasm; nuclear chromatin; nucleoplasm; nucleus; protein complex; transcription factor complex

Molecular Function: bHLH transcription factor binding; DNA binding; mitogen-activated protein kinase kinase kinase binding; protein binding; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding; transcription coactivator activity; transcription factor activity; transcription factor binding

Biological Process: B cell differentiation; B cell lineage commitment; immunoglobulin V(D)J recombination; negative regulation of transcription from RNA polymerase II promoter; positive regulation of B cell proliferation; positive regulation of cell cycle; positive regulation of muscle cell differentiation; positive regulation of neuron differentiation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; transcription, DNA-dependent
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