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TCF4 cdna clone

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Catalog # MBS1274157
Unit / Price
  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
TCF4 cdna clone
Product Name

TCF4, cDNA Clone

Popular Item
Also Known As

TCF4 cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
1098
Sequence
atgcatcacc aacagcgaat ggctgcctta gggacggaca aagagctgag tgatttactg gatttcagtg cgatgttttc acctcctgtg agcagtggga aaaatggacc aacttctttg gcaagtggac attttactgg ctcaaatgta gaagacagaa gtagctcagg gtcctggggg aatggaggac atccaagccc gtccaggaac tatggagatg ggactcccta tgaccacatg accagcaggg accttgggtc acatgacaat ctctctccac cttttgtcaa ttccagaata caaagtaaaa cagaaagggg ctcatactca tcttatggga gagaatcaaa cttacagggt tgccaccagc agagtctcct tggaggtgac atggatatgg gcaacccagg aaccctttcg cccaccaaac ctggttccca gtactatcag tattctagca ataatccccg aaggaggcct cttcacagta gtgccatgga ggtacagaca aagaaagttc gaaaagttcc tccaggtttg ccatcttcag tctatgctcc atcagcaagc actgccgact acaataggga ctcgccaggc tatccttcct ccaaaccagc aaccagcact ttccctagct ccttcttcat gcaagatggc catcacagca gtgacccttg gagctcctcc agtgggatga atcagcctgg ctatgcagga atgttgggca actcttctca tattccacag tccagcagct actgtagcct gcatccacat gaacgtttga gctatccatc acactcctca gcagacatca attccagtct tcctccgatg tccactttcc atcgtagtgg tacaaaccat tacagcacct cttcctgtac gcctcctgcc aacgggacag acagtataat ggcaaataga ggaagcgggg cagccggcag ctcccagact ggagatgctc tggggaaagc acttgcttcg atctattctc cagatcacac taacaacagc ttttcatcaa acccttcaac tcctgttggc tctcctccat ctctctcagc aggcacagct gtttggtcta gaaattga
OMIM
602272
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of TCF4 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for TCF4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48,098 Da
NCBI Official Full Name
Homo sapiens transcription factor 4, mRNA
NCBI Official Synonym Full Names
transcription factor 4
NCBI Official Symbol
NCBI Official Synonym Symbols
E2-2; ITF2; PTHS; SEF2; FECD3; ITF-2; SEF-2; TCF-4; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; bHLHb19
  [Similar Products]
NCBI Protein Information
transcription factor 4
UniProt Protein Name
Transcription factor 4
UniProt Synonym Protein Names
Class B basic helix-loop-helix protein 19; bHLHb19; Immunoglobulin transcription factor 2; ITF-2; SL3-3 enhancer factor 2; SEF-2
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
BHLHB19; ITF2; SEF2; TCF-4; bHLHb19; ITF-2; SEF-2  [Similar Products]
UniProt Entry Name
ITF2_HUMAN
NCBI Summary for TCF4
This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Jul 2016]
UniProt Comments for TCF4
TCF4: Transcription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription. Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. Efficient DNA binding requires dimerization with another bHLH protein. Forms homo- or heterooligomers with myogenin. Interacts with HIVEP2. Interacts with NEUROD2. Expressed in adult heart, brain, placenta, skeletal muscle and to a lesser extent in the lung. In developing embryonic tissues, expression mostly occurs in the brain. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 18q21.1

Cellular Component: nuclear chromatin; nucleus; transcription factor complex

Molecular Function: bHLH transcription factor binding; DNA binding; identical protein binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein homodimerization activity; transcription factor activity

Biological Process: positive regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein-DNA complex assembly; transcription initiation; transcription initiation from RNA polymerase II promoter

Disease: Corneal Dystrophy, Fuchs Endothelial, 3; Pitt-hopkins Syndrome
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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