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TET3 blocking peptide

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Catalog # MBS152112
Unit / Price
  0.05 mg  /  $140 +1 FREE 8GB USB
Western Blot (WB)
Product Name

TET3, Blocking Peptide

Popular Item
Also Known As

TET3 Peptide

Product Synonym Names
hCG_40738; KIAA0401; Methylcytosine dioxygenase TET3; TET methylcytosine dioxygenase 3
Antibody/Peptide Pairs
TET3 peptide (MBS152112) is used for blocking the activity of TET3 antibody (MBS151041)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
727
OMIM
613555
3D Structure
ModBase 3D Structure for O43151
Form/Format
Liquid
Concentration
200 ug/mL (lot specific)
Species
Human
Buffer
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
Location
17 amino acid peptide near the carboxy terminus of human TET3.
Preparation and Storage
Store TET3 peptide at -20 degree C, stable for one year.
Other Notes
Small volumes of TET3 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for TET3 blocking peptide
Blocking (BL)
Application Notes for TET3 blocking peptide
TET3 peptide is used for blocking the activity of TET3 antibody.

Western Blot (WB) of TET3 blocking peptide
Western blot analysis of TET3 in SK-N-SH cell lysate with TET3 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
TET3 blocking peptide Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for TET3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
77,471 Da
NCBI Official Synonym Full Names
tet methylcytosine dioxygenase 3
NCBI Official Symbol
NCBI Official Synonym Symbols
hCG_40738
  [Similar Products]
NCBI Protein Information
methylcytosine dioxygenase TET3
UniProt Protein Name
Methylcytosine dioxygenase TET3
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
KIAA0401  [Similar Products]
UniProt Entry Name
TET3_HUMAN
NCBI Summary for TET3
Members of the ten-eleven translocation (TET) gene family, including TET3, play a role in the DNA methylation process (Langemeijer et al., 2009 [PubMed 19923888]).[supplied by OMIM, Nov 2010]
UniProt Comments for TET3
TET3: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Conversion into 5hmC initiates a process leading to cytosine demethylation through deamination into 5-hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin. Belongs to the TET family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.11.n2; Oxidoreductase

Chromosomal Location of Human Ortholog: 2p13.1

Cellular Component: male pronucleus; cytoplasm; female pronucleus

Molecular Function: protein binding; DNA binding; metal ion binding

Biological Process: protein amino acid O-linked glycosylation; gene expression; positive regulation of transcription from RNA polymerase II promoter; regulation of gene expression, epigenetic
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withTET3 blocking peptide
 Reference Product  PubMed Publications
 NANOG blocking peptide  >5 publications with TET3 and NANOG
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