NP_001054.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
serotransferrin
NCBI Official Synonym Full Names
transferrin
NCBI Official Synonym Symbols
PRO1557; PRO2086; DKFZp781D0156 [Similar Products]
NCBI Protein Information
serotransferrin; siderophilin; OTTHUMP00000197155; beta-1 metal-binding globulin
UniProt Protein Name
Serotransferrin
UniProt Synonym Protein Names
Beta-1 metal-binding globulin; Siderophilin
UniProt Entry Name
TRFE_HUMAN
NCBI Summary for TF
This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq]
UniProt Comments for TF
Function: Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
Subunit structure: Monomer.
Subcellular location: Secreted.
Tissue specificity: Expressed by the liver and secreted in plasma.
Polymorphism: Different polymorphic variants of transferrin are known. The sequence shown is the predominant electrophoretic variant (C1 or TF*C1).
Involvement in disease: Defects in TF are the cause of atransferrinemia (ATRAF) [
MIM:209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia. Ref.4 Ref.39
Sequence similarities: Belongs to the transferrin family.Contains 2 transferrin-like domains.
Sequence caution: The sequence AAF22007.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
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Products associated with TF native protein
Pathways associated with TF native protein
Diseases associated with TF native protein
Organs/Tissues associated with TF native protein
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