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TF native protein :: Transferrin Native Protein

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Catalog # MBS537254
Unit / Price
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  1 mg  /  $285 +1 FREE 8GB USB
TF native protein
Product Name

Transferrin (TF), Native Protein

Popular Item
Full Product Name

Transferrin protein (HRP)

Product Synonym Names
TF protein; beta 1 metal binding globulin protein; Siderophilin protein; Apotransferrin protein; Serotransferrin precursor protein; DKFZp781D0156 protein; PRO2086 protein; PRO1400 protein; PRO1557 protein
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
190000
3D Structure
ModBase 3D Structure for P02787
Purity/Purification
Transferrin protein (HRP) was purified by selective precipitation and tandem chromatography followed by dialysis.
Form/Format
Supplied lyophilzed in 20mM Potassium Phosphate, 150mM Sodium Azide Chloride, pH 7.2, 10mg/ml BSA, with 0.01% Gentamicin Sulfate as preservative. Reconstitute with 1.0ml of deionized water. Do Not Add Sodium Azide!
Concentration
1.0 mg, lyophilized (lot specific)
Source
Human serum
Protein Type
Native
Note
A single precipitin arc was observed against anti-Peroxidase, anti-Human Transferrin and anti-Human serum, when assayed by Immunoelectrophoresis.
Preparation and Storage
Ships ambient or refridgerated. Upon receipt store at 4 degree C prior to reconstitution. For longer storage, aliquot and store at -20 degree C. Stable for serveral weeks at 4 degree C as an undiluted liquid.
Other Notes
Small volumes of TF native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
TF native protein
Transferrins are iron-binding blood plasma glycoproteins that control the level of free iron in biological fluids. In humans, it is encoded by the TF gene. Transferrin is a glycoprotein that binds iron very tightly but reversibly. Although iron bound to transferrin is less than 0.1% (4 mg) of the total body iron, it is the most important iron pool, with the highest rate of turnover (25 mg/24 h). Transferrin has a molecular weight of around 80 kDa and contains 2 specific high-affinity Fe(III) binding sites.
Applications Tested/Suitable for TF native protein
User optimized
NCBI/Uniprot data below describe general gene information for TF. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
transferrin
NCBI Official Synonym Full Names
transferrin
NCBI Official Symbol
NCBI Official Synonym Symbols
TFQTL1; PRO1557; PRO2086
  [Similar Products]
NCBI Protein Information
serotransferrin
UniProt Protein Name
Serotransferrin
UniProt Synonym Protein Names
Beta-1 metal-binding globulin; Siderophilin
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
Transferrin  [Similar Products]
UniProt Entry Name
TRFE_HUMAN
NCBI Summary for TF
This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]
UniProt Comments for TF
TF: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Defects in TF are the cause of atransferrinemia (ATRAF). Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia. Belongs to the transferrin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 3q22.1

Cellular Component: extracellular space; cell surface; cytoplasmic membrane-bound vesicle; early endosome; extracellular region; coated pit; recycling endosome; perinuclear region of cytoplasm; endocytic vesicle; late endosome; apical plasma membrane; basal plasma membrane; endosome membrane; vesicle

Molecular Function: protein binding; ferric iron binding; ubiquitin protein ligase binding

Biological Process: retinal homeostasis; platelet activation; platelet degranulation; cellular iron ion homeostasis; transferrin transport; blood coagulation; transmembrane transport

Disease: Atransferrinemia
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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