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anti-TFEB antibody :: anti-Human, Mouse TFEB Antibody

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Catalog # MBS855552
Unit / Price
  0.1 mg  /  $215 +1 FREE 8GB USB
Product Name

TFEB, Antibody

Popular Item
Full Product Name

TFEB Antibody

Product Synonym Names
Transcription factor EB; TFEB
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
600744
3D Structure
ModBase 3D Structure for P19484
Species Reactivity
Human, Mouse
Specificity
TFEB antibody detects endogenous levels of total TFEB protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from N-terminal of human TFEB.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-TFEB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-TFEB antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-TFEB antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:20000

Testing Data of anti-TFEB antibody
Peptide-+
anti-TFEB antibody Testing Data image
Immunohistochemistry (IHC) of anti-TFEB antibody
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using TFEB antibody. Western blot analysis of extracts from mouse lung cells and mouse muscle cells, using TFEB antibody.
anti-TFEB antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for TFEB. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,803 Da
NCBI Official Full Name
transcription factor EB isoform 2
NCBI Official Synonym Full Names
transcription factor EB
NCBI Official Symbol
NCBI Official Synonym Symbols
TCFEB; BHLHE35; ALPHATFEB
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NCBI Protein Information
transcription factor EB
UniProt Protein Name
Transcription factor EB
UniProt Synonym Protein Names
Class E basic helix-loop-helix protein 35; bHLHe35
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
BHLHE35; bHLHe35  [Similar Products]
UniProt Comments for TFEB
Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.
Product References and Citations for anti-TFEB antibody
Carr C.S., Mol. Cell. Biol. 10:4384-4388(1990). Kuiper R.P., Nucleic Acids Res. 32:2315-2322(2004). Mungall A.J., Nature 425:805-811(2003).

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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