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TGF-B1 recombinant protein :: Transforming Growth Factor Beta - 1 (TGF-B1) Recombinant Protein

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Catalog # MBS343178
Unit / Price
  0.01 mg  /  $230 +1 FREE 8GB USB
  0.1 mg  /  $600 +1 FREE 8GB USB
  1 mg  /  $2,750 +3 FREE 8GB USB
SDS-PAGE
Product Name

Transforming Growth Factor Beta - 1 (TGF-B1), Recombinant Protein

Also Known As

Transforming Growth Factor Beta - 1 (TGF-B1)

Product Synonym Names
TGF-1; TGF; TGF beta 1; TGF-b1., CED, DPD1, LAP
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
390
3D Structure
ModBase 3D Structure for P50414
Purity/Purification
>95% by SDS-PAGE
Form/Format
Liquid
Buffer
Buffered 50% glycerol
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of TGF-B1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
TGF-B1 recombinant protein
TGF beta 1 is a member of the larger TGF beta superfamily of cytokines produced by a wide variety of cells that are involved in the regulation of cell proliferation, differentiation, apoptosis, cellular homeostasis and a wide variety of other cellular functions. TGF beta 1 has been shown to regulate the actions of many other growth factors involved in a range of human diseases including renal disease, hepatic disease, heart failure and cardiomyopathies. Recombinant TGF beta-1 comprises a 112 amino acid fragment (279-390) corresponding to the mature TGF- beta protein sequence and is expressed in E Coli with an amino-terminal hexahistidine tag. This product is not intended for therapeutic use.

NCBI/Uniprot data below describe general gene information for TGF-B1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
44,291 Da
NCBI Official Full Name
transforming growth factor beta-1
NCBI Official Symbol
TGFB1  [Similar Products]
NCBI Protein Information
transforming growth factor beta-1
UniProt Protein Name
Transforming growth factor beta-1
UniProt Gene Name
TGFB1  [Similar Products]
UniProt Synonym Gene Names
TGF-beta-1; LAP  [Similar Products]
UniProt Entry Name
TGFB1_SHEEP
UniProt Comments for TGF-B1
Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP) (). Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus. Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types ().
Product References and Citations for TGF-B1 recombinant protein
Sporn MB et al., (1986) Science 233 (4763) 532-534

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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