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Thbs1 recombinant protein :: Thrombospondin-1 Recombinant Protein

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Catalog # MBS1265139
Unit / Price
Scan QR to view Datasheet
  0.01 mg (Yeast)  /  $200 +1 FREE 8GB USB
  0.01 mg (E-Coli)  /  $200 +1 FREE 8GB USB
  0.05 mg (E-Coli)  /  $260 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $260 +1 FREE 8GB USB
  0.1 mg (Yeast)  /  $430 +1 FREE 8GB USB
  0.1 mg (E-Coli)  /  $430 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $680 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $685 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,120 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,125 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,725 +2 FREE 8GB USB
  1 mg (Yeast)  /  $1,730 +2 FREE 8GB USB
SDS-Page
Product Name

Thrombospondin-1 (Thbs1), Recombinant Protein

Popular Item
Full Product Name

Recombinant Mouse Thrombospondin-1

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
19-350aa; Partial
Sequence
NRIPESGGDN GVFDIFELIG GARRGPGRRL VKGQDLSSPA FRIENANLIP AVPDDKFQDL LDAVWADKGF IFLASLRQMK KTRGTLLAVE RKDNTGQIFS VVSNGKAGTL DLSLSLPGKQ QVVSVEEALL ATGQWKSITL FVQEDRAQLY IDCDKMESAE LDVPIQSIFT RDLASVARLR VAKGDVNDNF QGVLQNVRFV FGTTPEDILR NKGCSSSATN VLLTLDNNVV NGSSPAIRTN YIGHKTKDLQ AICGLSCDEL SSMVLELKGL RTIVTTLQDS IRKVTEENRE LVSELKRPPL CFHNGVQYKN NEEWTVDSCT ECHCQNSVTI CK
3D Structure
ModBase 3D Structure for P35441
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater than 90% as determined by SDS-PAGE. (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of Thbs1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Thbs1 recombinant protein
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp. Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors. 1 Publication

Thbs1 recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
NCBI/Uniprot data below describe general gene information for Thbs1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
40.7kD
NCBI Official Full Name
Thrombospondin-1
NCBI Official Synonym Full Names
thrombospondin 1
NCBI Official Symbol
Thbs1  [Similar Products]
NCBI Official Synonym Symbols
TSP1; TSP-1; tbsp1; Thbs-1
  [Similar Products]
NCBI Protein Information
thrombospondin-1
UniProt Protein Name
Thrombospondin-1
Protein Family
UniProt Gene Name
Thbs1  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
TSP1_MOUSE
NCBI Summary for Thbs1
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
UniProt Comments for Thbs1
THBS1: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp. Ligand for CD36 mediating antiangiogenic properties. Belongs to the thrombospondin family.

Protein type: Motility/polarity/chemotaxis; Inhibitor

Cellular Component: cell surface; cytoplasm; endoplasmic reticulum; external side of plasma membrane; extracellular matrix; extracellular region; extracellular space; fibrinogen complex; sarcoplasmic reticulum; secretory granule

Molecular Function: calcium ion binding; extracellular matrix binding; fibroblast growth factor binding; fibronectin binding; heparin binding; integrin binding; laminin binding; low-density lipoprotein binding; phosphatidylserine binding; protein binding; transforming growth factor beta binding

Biological Process: activation of MAPK activity; behavioral response to pain; blood vessel morphogenesis; cell adhesion; cell cycle arrest; cell migration; engulfment of apoptotic cell; inflammatory response; negative regulation of angiogenesis; negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; negative regulation of apoptosis; negative regulation of blood vessel endothelial cell migration; negative regulation of caspase activity; negative regulation of cell-matrix adhesion; negative regulation of dendritic cell antigen processing and presentation; negative regulation of endothelial cell proliferation; negative regulation of fibrinolysis; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of interleukin-12 production; peptide cross-linking; positive regulation of angiogenesis; positive regulation of blood coagulation; positive regulation of blood vessel endothelial cell migration; positive regulation of cell migration; positive regulation of chemotaxis; positive regulation of macrophage activation; positive regulation of phosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of translation; positive regulation of tumor necrosis factor biosynthetic process; regulation of cGMP metabolic process; response to calcium ion; response to glucose stimulus; response to magnesium ion; response to mechanical stimulus; response to unfolded protein; sprouting angiogenesis
Product References and Citations for Thbs1 recombinant protein
Characterization of the murine thrombospondin gene.Lawler J., Duquette M., Ferro P., Copeland N.G., Gilbert D.J., Jenkins N.A.Genomics 11:587-600(1991) Characterization of mouse thrombospondin 2 sequence and expression during cell growth and development.Laherty C.D., O'Rourke K., Wolf F.W., Katz R., Seldin M.F., Dixit V.M.J. Biol. Chem. 267:3274-3281(1992) Characterization of the mouse thrombospondin gene and evaluation of the role of the first intron in human gene expression.Bornstein P., Alfi D., Devarayalu S., Framson P., Li P.J. Biol. Chem. 265:16691-16698(1990) Expression and initial characterization of recombinant mouse thrombospondin 1 and thrombospondin 3.Chen H., Aeschlimann D., Nowlen J., Mosher D.F.FEBS Lett. 387:36-41(1996) The mouse C2C12 myoblast cell surface N-linked glycoproteome identification, glycosite occupancy, and membrane orientation.Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.Mol. Cell. Proteomics 8:2555-2569(2009) A thrombospondin-dependent pathway for a protective ER stress response.Lynch J.M., Maillet M., Vanhoutte D., Schloemer A., Sargent M.A., Blair N.S., Lynch K.A., Okada T., Aronow B.J., Osinska H., Prywes R., Lorenz J.N., Mori K., Lawler J., Robbins J., Molkentin J.D.Cell 149:1257-1268(2012)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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