NP_116597.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
38,592 Da
NCBI Official Full Name
4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase
NCBI Protein Information
4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase
UniProt Protein Name
4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI5
UniProt Synonym Protein Names
Thiamine biosynthesis protein 5
UniProt Synonym Gene Names
UniProt Comments for THI5
Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.
Research Articles on THI5
Precautions
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Disclaimer
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Products associated with THI5 recombinant protein
Pathways associated with THI5 recombinant protein
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