NP_002763.2
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
enteropeptidase
NCBI Official Synonym Full Names
transmembrane protease, serine 15
NCBI Official Synonym Symbols
NCBI Protein Information
enteropeptidase; enterokinase; serine protease 7; protease, serine, 7 (enterokinase)
UniProt Protein Name
Enteropeptidase
UniProt Synonym Protein Names
Enterokinase; Serine protease 7; Transmembrane protease serine 15
UniProt Synonym Gene Names
UniProt Entry Name
ENTK_HUMAN
NCBI Summary for TMPRSS15
This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive. [provided by RefSeq, Jul 2008]
UniProt Comments for TMPRSS15
Function: Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.
Catalytic activity: Activation of trypsinogen by selective cleavage of 6-Lys-|-Ile-7 bond.
Subunit structure: Heterodimer of a catalytic (light) chain and a multidomain (heavy) chain linked by a disulfide bond.
Subcellular location: Membrane; Single-pass type II membrane protein
Probable.
Tissue specificity: Intestinal brush border.
Post-translational modification: The chains are derived from a single precursor that is cleaved by a trypsin-like protease.
Involvement in disease: Enterokinase deficiency (ENTKD) [MIM:226200]: Life-threatening intestinal malabsorption disorder characterized by diarrhea and failure to thrive.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.2
Sequence similarities: Belongs to the peptidase S1 family.Contains 2 CUB domains.Contains 2 LDL-receptor class A domains.Contains 1 MAM domain.Contains 1 peptidase S1 domain.Contains 1 SEA domain.Contains 1 SRCR domain.
Sequence caution: The sequence CAB90389.1 differs from that shown. Reason: Erroneous gene model prediction.
Research Articles on TMPRSS15
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
|