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TMSB4X native protein :: Thymosin-b4 Native Protein

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Catalog # MBS142668
Unit / Price
  1 mg  /  $205 +1 FREE 8GB USB
  5 mg  /  $595 +1 FREE 8GB USB
  25 mg  /  $1,900 +2 FREE 8GB USB
TMSB4X native protein
Product Name

Thymosin-b4 (TMSB4X), Native Protein

Popular Item
Also Known As

Thymosin-b4

Product Synonym Names
Thymosin beta4; Thymosin beta4; Thymosin b4; Thymosin beta-4; T beta 4; Fx; TB4X; PTMB4; TMSB4; Thymosin beta4
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
44
Sequence
Thymosin b4 has an a.a. sequence of Ac-Ser-Asp -Lys-Pro-A sp-Met-Ala -Glu-Ile-G lu-Lys-Phe -Asp-Lys-S er-Lys-Leu -Lys-Lys-T hr-Glu-Thr -Gln-Glu-L ys-Asn-Pro -Leu-Pro-S er-Lys-Glu -Thr-Ile-G lu-Gln-Glu -Lys-Gln-A la-Gly-Glu -Ser-OH
OMIM
300159
3D Structure
ModBase 3D Structure for P62328
Purity/Purification
Greater than 98.0% as determined by RP-HPLC.
Form/Format
The protein (1 mg/ml) was lyophilized with no additives.
Sterile Filtered White lyophilized (freeze-dried) powder.
Solubility
It is recommended to reconstitute the lyophilized Thymosin beta-4 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Preparation and Storage
Lyophilized Thymosin b4 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution T beta 4 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Other Notes
Small volumes of TMSB4X native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
TMSB4X native protein
Description: Thymosin b4 is a 43 amino acid peptide which is regarded as the main intracellular G-actin sequestering peptide.It has a molecular weight of 4963.55 Da, and its molecular formula is: C212H350N56O78S1. Extracellular Thymosin b4 may contribute to physiological processes such as angiogenesis, wound healing, and regulation of inflammation. Thymosin b4 has an a.a. sequence of Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH.

Introduction: Thymosin is a hormone secreted from the thymus. Its primary function is to stimulate the production of T cells, which are an important part of the immune system. Thymosin also assists in the development of B cells to plasma cells to produce antibodies. The predominant form of thymosin, thymosin b4, is a member of a highly conserved family of actin monomer-sequestering proteins. b-thymosins are the primary regulators of unpolymerized actin, and are essential for maintaining the small cytoplasmic pool of free G-actin monomers required for rapid filament elongation and allowing for the flux of monomers between the thymosin-bound pool and F-actin.
Product Categories/Family for TMSB4X native protein
NCBI/Uniprot data below describe general gene information for TMSB4X. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
NCBI Official Full Name
thymosin beta-4
NCBI Official Synonym Full Names
thymosin beta 4, X-linked
NCBI Official Symbol
TMSB4X  [Similar Products]
NCBI Official Synonym Symbols
FX; TB4X; PTMB4; TMSB4
  [Similar Products]
NCBI Protein Information
thymosin beta-4; prothymosin beta-4; t beta-4; thymosin, beta 4, X chromosome
UniProt Protein Name
Thymosin beta-4
UniProt Synonym Protein Names
FxHematopoietic system regulatory peptideAlternative name(s):Seraspenide
Protein Family
UniProt Gene Name
TMSB4X  [Similar Products]
UniProt Synonym Gene Names
TB4X; THYB4; TMSB4; T beta-4  [Similar Products]
UniProt Entry Name
TYB4_HUMAN
NCBI Summary for TMSB4X
This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008]
UniProt Comments for TMSB4X
TMSB4X: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: Xq21.3-q22

Cellular Component: cytoskeleton; extracellular region

Molecular Function: actin monomer binding; protein binding

Biological Process: platelet activation; platelet degranulation; sequestering of actin monomers; actin filament organization; blood coagulation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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