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TNF beta recombinant protein

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Catalog # MBS538190
Unit / Price
  0.02 mg  /  $310 +1 FREE 8GB USB
TNF beta recombinant protein
Product Name

TNF beta, Recombinant Protein

Also Known As

TNF beta protein

Product Synonym Names
LT-alpha protein; TNFSF1 protein; TNF-b protein; Tumor Necrosis Factor-beta protein; TNF-beta protein; Lymphotoxin-alpha protein; TNFb protein
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
242
Sequence
Region of TNF beta protein correspond ing to amino acids MLPGVGLTPS AAQTARQHPK MHLAHSTLKP AAHLIGDPSK QNSLLWRANT DRAFLQDGFS LSNNSLLVPT SGIYFVYSQV VFSGKAYSPK ATSSPLYLAH EVQLFSSQYP FHVPLLSSQK MVYPGLQEPW LHSMYHGAAF QLTQGDQLST HTDGIPHLVL SPSTVFFGAF AL.
3D Structure
ModBase 3D Structure for Q1JQ40
Host
Human
Purity/Purification
> 98% pure
Form/Format
Lyophilized from 10mM Na3PO4, pH 7.0, with 50 mM NaCl. Reconstitute in Water to a concentration of 0.1-1.0 mg/ml.
Protein Type
Recombinant
Biological Significance
TNF-beta is a potent mediator of inflammatory and immune responses. It belongs to the TNF family of ligands and signals through TNFR1 and TNFR2. TNF-beta is produced by activated T and B lymphocytes, and has similar activities to TNF-alpha. Like TNF-alpha, TNF-beta is involved in the regulation of various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. TNF-beta is secreted as a soluble polypeptide, but can form heterotrimers with lymphotoxin-beta, which effectively anchors the TNF-beta to the cell surface. TNF-beta is cytotoxic to a wide range of tumor cells.
Bioactivity
The ED50 as determined by the cytolysis of Mouse L929 cells in the presence of Actinomycin-D is approximately 0.05 ng/ml, corresponding to a specific activity of approximately 2 x 10^7 units/mg.
Endotoxin Levels
Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Expression System
E Coli
Preparation and Storage
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of TNF beta recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
TNF beta recombinant protein
Purified recombinant Human TNF beta protein
Product Categories/Family for TNF beta recombinant protein
Applications Tested/Suitable for TNF beta recombinant protein
User optimized
NCBI/Uniprot data below describe general gene information for TNF beta. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
Molecular Weight
18.6 kDa
NCBI Official Full Name
Tumor necrosis factor b (TNF superfamily, member 2)
NCBI Official Synonym Full Names
tumor necrosis factor b (TNF superfamily, member 2)
NCBI Official Symbol
NCBI Official Synonym Symbols
tnf; Tnf-alpha; tnfa-like
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NCBI Protein Information
tumor necrosis factor (TNF superfamily, member 2)
UniProt Protein Name
Tnfb protein
UniProt Synonym Protein Names
Tnfb protein
UniProt Gene Name
UniProt Entry Name
Q1JQ40_DANRE
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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